34273-12-6

Basic information

• Product Name: H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH
• Synonyms: ANGIOTENSIN 1/2 (1-9);ANGIOTENSIN (1-9);ANGIOTENSIN I (1-9);H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH;H2N-DRVYIHPFH-OH;DRVYIHPFH;Des-Leu angiotensin I【human】;L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-OH
• CAS NO: 34273-12-6
• Molecular Formula: C56H78N16O13
• Molecular Weight: 1183.32
• Product Categories: peptide;SignalTransduction
• Mol File: 34273-12-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• Solubility: ≥118.3 mg/mL in DMSO; insoluble in EtOH; ≥51 mg/mL in H2O
• CAS DataBase Reference: H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH(34273-12-6)
• EPA Substance Registry System: H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH(34273-12-6)

Safety Data

• Hazardous Substances Data: 34273-12-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Biological Activity

angiotensin i/ii (1-9) is a peptide (asp-arg-val-tyr-ile-his-pro-phe-his) containing the amino acids 1-9 that are converted from angiotensin i/ii peptide.angiotensin i is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. renin cleaves the peptide bond between the leucine (leu) and valine (val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin i. angiotensin i is converted to angiotensin ii (aii) through removal of two c-terminal residues by the enzymeangiotensin-converting enzyme (ace), primarily through ace within the lung.angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up.figure1 formula of angiotensin i/ii (1-9)

references

1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9. 2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.

Relevant articles and documents

Synthesis of peptides with the solid phase method. II. Octapeptide analogues of angiotensin II

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