346-18-9 Usage
Description
Polythiazide (200 MG) is a thiazide diuretic medication, characterized by its crystalline or white powder form. It is known for its more pronounced antihypertensive effect compared to chlorothiazide and is primarily used in combination with other drugs for the treatment of various conditions related to high blood pressure and fluid retention.
Uses
Used in Pharmaceutical Industry:
Polythiazide (200 MG) is used as an active ingredient in the treatment of hypertension for managing high blood pressure. It is particularly effective in cases where other diuretics, such as chlorothiazide, may not be as efficient.
Used in Nephrotic Syndrome Treatment:
Polythiazide (200 MG) is used as a diuretic agent for the management of nephrotic syndrome, a condition characterized by excessive protein loss in urine, leading to swelling and other complications.
Used in Liver Cirrhosis Management:
In cases of liver cirrhosis, Polythiazide (200 MG) is used as a diuretic to help reduce the accumulation of fluid in the abdomen, a common issue in patients with this condition.
Used in Nutritional Edema Treatment:
Polythiazide (200 MG) is utilized as a diuretic to treat nutritional edema, a condition resulting from an imbalance of fluids in the body, often caused by malnutrition or protein deficiency.
Used in Combination Drugs:
Polythiazide (200 MG) is used as an ingredient in combination drugs, such as minizide, which is a mixture of prazozine and polythiazide. This combination is specifically designed to lower blood pressure more effectively than using either drug alone.
Brand Name:
Renese (Pfizer) is a brand name under which Polythiazide (200 MG) is marketed, providing patients with a reliable and recognized source for this medication.
Originator
Renese ,Pfizer, US ,1961
Manufacturing Process
(A) Preparation of trifluoroethylthioacetaldehyde dimethylacetal: To 4.6 g (0.2 mol) of metallic sodium dissolved in 75 ml of absolute methanol is rapidly added 24.4 g (0.2 mol) of mercaptoacetaldehyde dimethylacetal followed by dropwise addition of 42.0 g (0.2 mol) of trifluoroethyl iodide.The resulting reddish mixture is refluxed on a steam bath for one hour. One half of the alcohol is removed by concentration and the remainder diluted with several volumes of water and extracted with ether. The combined ether extracts are dried over sodium sulfate, the ether then removed at reduced pressure and the residue distilled to about 30 g (BP 82°C/25 mm).(B) Preparation of 4-Amino-2-Chloro-5-(Methylsulfamyl)Benzenesulfonamide: The 5-substituted-2,4-disulfamyl anilines may be prepared by procedures described in the literature, for example, the general procedures in Monatsch. Chem. vol. 48, p 87 (1927), which involves the treatment of a m-substituted aniline with from 10 to 20 parts by weight of chlorosulfonic acid followed by the gradual addition of from about 90 to 170 parts by weight of sodium chloride. The resultant mixture is heated at approximately 150°C for about 2hours after which the reaction mixture is poured into water and the resultant 5substituted aniline-2,4-disulfonyl chloride is filtered and is then treated with concentrated ammonium hydroxide or suitable amine by standard procedures to obtain the corresponding disulfonamide.(C) Preparation of 2-Methyl-3-(2,2,2-Trifluoroethyl)Thiomethyl-6-Chloro-7Sulfamyl-3,4-Dihydro-1,2,4-Benzothiadiazine-1,1-Dioxide: To 4.6 g (0.015 mol) of 4-amino-2-chloro5-(methylsulfamyl)benzenesulfonamide in 30 ml of the dimethyl ether of ethylene glycol is added 4.08 g (0.02 mol) of 2,2,2trifluoroethylmercaptoacetaldehyde dimethylacetal followed by 1 ml of ethyl acetate saturated with hydrogen chloride gas. The resulting solution is refluxed for 1.5 hours, cooled and then slowly added to cold water dropwise with stirring. The crude product is filtered, dried and recrystallized from isopropanol (3.2 g), MP 202° to 202.5°C. A second recrystallization from isopropanol raised the MP to 202° to 203°C.
Therapeutic Function
Diuretic
Air & Water Reactions
Its rate of decomposition in solution increases with an increase in pH. . Insoluble in water.
Reactivity Profile
POLYTHIAZIDE (200 MG) is a sulfonamide derivative. With strong reducing agents will produce hydrogen sulfide gas.
Fire Hazard
Flash point data for POLYTHIAZIDE (200 MG) are not available, but POLYTHIAZIDE (200 MG) is probably combustible.
Synthesis
Polythiazide, 1,1-dioxide 2-methyl-3-(2,2,2-trifluoroethylthiomethyl)-6-
chloro-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.8), is also synthesized
by an analogous scheme, which is by condensing 4-aminosulfonyl-5-chloro-2-methylaminosulfonylaniline
(21.3.7) with 2,2,2-trifluoroethylthioacetaldehyde dimethylacetal.
Check Digit Verification of cas no
The CAS Registry Mumber 346-18-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 346-18:
(5*3)+(4*4)+(3*6)+(2*1)+(1*8)=59
59 % 10 = 9
So 346-18-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)
