352438-07-4

Basic information

• Product Name: 2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-
• Synonyms: (+/-)-3-propionyl-4-benzyl-2-oxazolidinone;4-benzyl-3-propionyl-2-oxazolidinone;N-propionyl (4S)-4-benzyl-2-oxazolidinone;rac-4-benzyl-N-propionyl-2-oxazolidinone;benzylpropionyloxazolidinone;4-Benzyl-3-propionyl-oxazolidin-2-one;4-(S)-Benzyl-3-propionyl-2-oxazolidinone
• CAS NO: 352438-07-4
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Mol File: 352438-07-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-(352438-07-4)
• EPA Substance Registry System: 2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-(352438-07-4)

Safety Data

• Hazardous Substances Data: 352438-07-4(Hazardous Substances Data)

Upstream product

• 90719-32-7 4-benzyl-2-oxazolidinone 
• 79-03-8 propionyl chloride 

Downstream Products

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 1616376-34-1 (4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one 
• 881031-81-8 C₃₃H₄₁NO₆Si 
• 468756-89-0 (4S,2'S,3'R)-N-(3-acetoxy-2-methylbutanoyl)-4-benzyl-2-oxazolidinone 
• 851955-71-0 (2R,3S,4S)-7-Benzyloxy-3-hydroxy-2,4-dimethyl-heptanoic acid methoxy-methyl-amide 

Relevant articles and documents

New Routes to Chiral Evans Auxiliaries by Enzymatic Desymmetrisation and Resolution Strategies

This paper describes how enantiomerically enriched Evans auxiliaries can be successfully prepared by either an enzymatic desymmetrisation strategy or an asymmetric synthesis using racemic auxiliaries and an enzymatic resolution. Desymmetrisation of N-Boc-protected serinol has been achieved in good yield and high enantiomeric excess using porcine pancreas lipase. This has been exploited in different ways to prepare enantiomerically enriched (4R)- and (4S)-substituted 2-oxazolidinones. In another approach to asymmetric synthesis, starting from a racemic Evans auxiliary, by means of a diastereoselective aldol reaction coupled with a lipase-catalysed resolution, we achieved the preparation of enantiomerically enriched β-hydroxy acids and enantiomerically enriched 2-oxazolidinones.