35803-45-3

Basic information

• Product Name: URACIL-2-13C
• Synonyms: URACIL-2-13C;URACIL-2-13C, 99 ATOM % 13C
• CAS NO: 35803-45-3
• Molecular Formula: C4H4N2O2
• Molecular Weight: 113.1
• Product Categories: Alphabetical Listings;Stable Isotopes;U-Z
• Mol File: 35803-45-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300 °C (dec.)(lit.)
• Appearance: /
• Density: 1.322g/cm³
• Refractive Index: 1.502
• CAS DataBase Reference: URACIL-2-13C(CAS DataBase Reference)
• NIST Chemistry Reference: URACIL-2-13C(35803-45-3)
• EPA Substance Registry System: URACIL-2-13C(35803-45-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 35803-45-3(Hazardous Substances Data)

Usage

Description

URACIL-2-13C, also known as 2,4(1H,3H)-Pyrimidinedione-2-13C, is a stable isotope-labeled analog of Uracil (U801000). It is a compound that contains the stable isotope carbon-13 (13C) at the second position of the pyrimidine ring, which distinguishes it from the naturally occurring unlabeled uracil. This labeled analog is utilized in various applications due to its unique properties and ability to be detected in specific tests.

Uses

Used in Medical Diagnostics:
URACIL-2-13C is used as a diagnostic agent for identifying dihydropyrimidine dehydrogenase (DPD) deficiency through a breath test. DPD is a crucial enzyme involved in the metabolism of various pyrimidine-based drugs and is essential for the breakdown of uracil. By administering URACIL-2-13C and monitoring the exhaled breath for the presence of labeled carbon dioxide, healthcare professionals can determine if a patient has a deficiency in DPD enzyme activity. This information is vital for personalized treatment planning, as DPD deficiency can lead to severe side effects and toxicities when patients are prescribed certain medications.

InChI:InChI=1/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)/i4+1

Upstream product

• 58069-82-2 13C urea 
• 471-25-0 Propiolic acid 

Relevant articles and documents

Synthesis and purification of [2-13C]-5-fluorouracil

[2-13C]-5-Fluoropyrimidine-2,4(1H,3H)-dione ([2- 13C]-5-fluorouracil or [2-13C]-5-FU) is a potential diagnostic agent for measuring 5-FU-induced toxicity in cancer patients. It was prepared and purified with isotopic and chemical purity of>99% on a multigram scale in a two-step synthesis from [13C]-urea. Preparative separation of [2-13C]-FU and [2-13C]-uracil was carried out by automated medium pressure silica gel column chromatography. The method is applicable to a broader range of 5-FU isotopic analogs derived from labeled uracil. Copyright 2011 John Wiley & Sons, Ltd. [2- 13C]-5-Fluoropyrimidine-2,4(1H,3H)-dione ([2-13C]-5- fluorouracil or [2-13C]-5-FU) is a potential diagnostic agent for measuring 5-FU-induced toxicity in cancer patients. It was prepared and purified with isotopic and chemical purity of >99% on a multigram scale in a two-step synthesis from [13C]-urea. Preparative separation of [2- 13C]-FU and [2-13C]-urea was carried out by medium pressure automated silica gel column chromatography. The method is applicable to a broader range of 5-FU isotopic analogs derived from labeled uracil. Copyright

Synthesis of 13C-labelled compounds having a urea unit, and observation of 13C-isotope effect in their infrared spectra

Various drugs and nucleic acids containing a urea unit were synthesized from [13C]urea. The 13C-isotope effect in the infrared spectra of these compounds was examined.