38528-41-5Relevant articles and documents
Anticancer Activity of 2-Amino-substituted-1,4-naphthoquinone Derivatives in Ovarian Cancer Cells
Shin, Sujeong,Lee, Haneul,Jeon, Cheolmin,Preya, Umma Hafsa,Choi, Jung-Hye,Park, Jeong Ho
, p. 1411 - 1414 (2017)
2-Amino-substituted-1,4-naphthoquinone derivatives (10–17) were synthesized from coupling reaction between 1,4-dihydroxynaphthalene and amines in the presence of catalyst CeCl3.7H2O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC50 10 μM) on all three ovarian cancer cells.
Synthesis and screening of substituted 1,4-naphthoquinones (NPQs) as antifilarial agents
Mathew, Nisha,Karunan, Twinkle,Srinivasan, Lakshmy,Muthuswamy, Kalyanasundaram
experimental part, p. 188 - 196 (2011/10/30)
Eleven amino-substituted 1,4-naphthoquinones were synthesized via the reaction of 1,4-naphthoquinone with different primary and secondary mono- and diamines in the presence of dichloromethane ethanol (1:2) solvent at room temperature. All compounds were p