4111-55-1

Basic information

• Product Name: LITHIUM DICYCLOHEXYLAMIDE
• Synonyms: N-Lithiodicyclohexylamine;LITHIUM DICYCLOHEXYLAMIDE;(Dicyclohexylamino)lithium;Lithiodicyclohexylamine;N-Lithiobis(cyclohexyl)amine;LiN(Cy)2;lithium,dicyclohexylazanide
• CAS NO: 4111-55-1
• Molecular Formula: C₁₂H₂₂LiN
• Molecular Weight: 187.25
• EINECS: 223-894-6
• Product Categories: Chemical Synthesis;Organic Bases;Synthetic Reagents
• Mol File: 4111-55-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 256.1°Cat760mmHg
• Flash Point: 96.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0157mmHg at 25°C
• CAS DataBase Reference: LITHIUM DICYCLOHEXYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: LITHIUM DICYCLOHEXYLAMIDE(4111-55-1)
• EPA Substance Registry System: LITHIUM DICYCLOHEXYLAMIDE(4111-55-1)

Safety Data

• Hazard Codes: F,C
• Statements: 17-34
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 3393 4.2/PG 1
• WGK Germany: 3
• HazardClass: 4.2
• PackingGroup: I
• Hazardous Substances Data: 4111-55-1(Hazardous Substances Data)

Usage

Description

LITHIUM DICYCLOHEXYLAMIDE is a chemical compound that serves as an essential reagent in the synthesis of various organic compounds, particularly in the preparation of 2-Dihalo-ribolactones. These ribolactones are synthons for antiviral nucleosides, which are crucial in the development of antiviral medications.

Uses

Used in Pharmaceutical Industry:
LITHIUM DICYCLOHEXYLAMIDE is used as a reagent for the synthesis of 2-Dihalo-ribolactones, which are essential synthons for antiviral nucleosides. The application reason is to facilitate the development of antiviral medications that can help combat viral infections and diseases.
In the context of the provided materials, LITHIUM DICYCLOHEXYLAMIDE plays a significant role in the preparation of 2-Dihalo-ribolactones through coupling reactions. This process is vital for the creation of antiviral nucleosides, which are essential components in the formulation of antiviral drugs. By using LITHIUM DICYCLOHEXYLAMIDE in this process, researchers and pharmaceutical companies can develop more effective antiviral medications to address the growing need for treatments against various viral diseases.

InChI:InChI=1/C12H22N.Li/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;/h11-12H,1-10H2;/q-1;+1

Upstream product

• 17789-14-9 3-(1,3-dioxolan-2-yl)-phenylbromide 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 917-54-4 methyllithium 
• 110426-35-2 C₂₁H₂₇Li 
• 68695-92-1 (4,4'-Dimethyldiphenylmethyl)lithium 
• 881-42-5 diphenylmethyllithium 

Downstream Products

• 22699-63-4 N,N-dicyclohexylformamide 
• 82024-47-3 N,N,N',N'-tetracyclohexylhydroxymalonamide 
• 83862-72-0 N,N-dicyclohexylglyoxylamide hemihydrate 
• 42843-43-6 N-dicyclohexyl-p-toluenesulfinamide 
• 100-61-8 N-methylaniline 
• 110-89-4 piperidine 
• 4706-32-5 2-oxo-2-(piperidin-1-yl)acetaldehyde 
• 7560-83-0 N-Methyldicyclohexylamine 
• 110-91-8 morpholine 
• 16423-59-9 2-(morpholin-4-yl)-2-oxoacetaldehyde 
• 500997-68-2 N,N-dicyclohexyl-[(R)-1,1'-spirobiindane-7,7'-diyl]phosphoramidite 
• 60760-63-6 (CH₃)2SbN(c-C₆H₁₁)2 

Relevant articles and documents

Synthesis of trisubstituted alkenylstannanes through copper-catalyzed three-component coupling of alkylboranes, alkynoates, and tributyltin methoxide

A versatile route to trisubstituted alkenylstannanes is presented. The alkyl and Sn moieties were introduced at the β and α carbon atoms of alkynoates, respectively, in a formal syn addition mode with complete regioselectivity (see scheme). A variety of functional groups were tolerated in the alkylboranes and alkynoates. Copyright

An organocatalytic asymmetric nazarov cyclization

An organocatalytic asymmetric Nazarov cyclization of diketoesters that proceeds by means of a dual activation mechanism has been developed. Screening of a number of catalysts led to a new thiourea that incorporates a primary amino group. The method gives rise to cyclic products with two adjacent quaternary asymmetric carbon atoms, one of which is an all-carbon stereocenter, with complete or nearly complete diastereoselectivity and in high or very high enantiomeric excess. A brief and very convenient synthesis of the acyclic diketoester starting materials through nucleophilic addition to a ketene is also described.

AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.