4741-99-5Relevant articles and documents
Polyamines XIV. Protonation Equilibria of Linear Tetraamines Containing two Ethylenediamine Residues
Anderegg, Giorgio,Blaeuenstein, Peter
, p. 162 - 169 (1982)
The syntheses of the linear tetraamines H2N-(CH2)2-NH-(CH2)n-NH-(CH2)2-NH2 (n = 4 and 5) are described.The protonation of the homologous tetraamines for n = 2, 3, 4, 5, 6 and 8, as well as of N-methylethylenediamine, was investigated using potentiometric and calorimetric measurements.The results obtained are discussed taking into consideration the substituent effect on the basicity of the aminic N-atoms.
Therapeutic and diagnostic domain 1 beta2GP1 polypeptides and methods of using same
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, (2008/06/13)
The present invention provides domain 1 β2GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β2GPI polypeptides and mimetics. Domain 1 of β2GPI has been shown to bind to anti-cardiolipin (β2GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 β2GPI polypeptides may be used to detect β2GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 β2GPI polypeptides.
Valency platform molecules comprising aminooxy groups
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, (2008/06/13)
Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.
Phenylglyoxal for polyamines modification and cyclam synthesis
Tripier, Rapha?l,Chuburu, Fran?oise,Le Baccon, Michel,Handel, Henri
, p. 4573 - 4579 (2007/10/03)
The bis-aminals obtained by tetraamine and phenylglyoxal condensation display various behaviours such as equilibrium between different configurations, rearrangements that lead to lactam derivatives, or amine deprotection. Our investigations about them were focused on three different linear amines, and then extended to polyazacycloalkanes cyclen and cyclam. Cyclam was also synthesised with the bis-aminals issued from condensation of linear polyamines with phenylglyoxal. The lactam derivatives described here were moreover, employed for the mono-N-functionalisation of tetraamines by phenyl-acetic acid group.