494773-45-4

Basic information

• Product Name: 1,3-Benzenediol, 4-bromo-, 1-(4-methylbenzenesulfonate)
• CAS NO: 494773-45-4
• Molecular Formula: C13H11BrO4S
• Molecular Weight: 343.198
• Mol File: 494773-45-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenediol, 4-bromo-, 1-(4-methylbenzenesulfonate)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenediol, 4-bromo-, 1-(4-methylbenzenesulfonate)(494773-45-4)
• EPA Substance Registry System: 1,3-Benzenediol, 4-bromo-, 1-(4-methylbenzenesulfonate)(494773-45-4)

Safety Data

• Hazardous Substances Data: 494773-45-4(Hazardous Substances Data)

Upstream product

• 6626-15-9 4-Bromoresorcinol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 328945-92-2 4-bromo-3-(methoxymethoxy)phenyl 4-methylbenzenesulfonate 
• 913648-31-4 toluene-4-sulfonic acid 4-bromo-3-(2-methoxymethoxyethoxy)phenyl ester 
• 70120-19-3 5-(benzyloxy)-2-bromophenol 
• 235091-20-0 4-(benzyloxy)-1-bromo-2-(methoxymethoxy)benzene 

Relevant articles and documents

ANTI-PARASITIC COMPOUNDS

Provided are compounds, methods, and pharmaceutical compositions useful for treatment of parasites, e.g., Leishmania. For example, the compound may he represented by Ar—C(=NR1)NR2—A—X—Y—Het2, and pharmaceutically acceptable salts thereof. Ar may be an optionally substituted, aryl or nitrogen-containing heteroaryl. R1 and R2 may independently represent H, optionally substituted C1-C6 alkyl, or optionally substituted C3-C6 cycloalkyl. A may be a bond or an optionally substituted linking moiety comprising 1, 2, or 3 rings. Each ring in the optionally substituted linking moiety may independently be one of: aryl, cycloalkyl, heterocycloalkyl, and heteroaryl. X may be O, S, amide, or a bond. Y may be optionally substituted C1-C14 alkyl or optionally substituted C2-C14 alkenyl. Het2 may be an optionally substituted five-membered nitrogen-containing heteroaromatic ring comprising 1, 2, or 3 ring heteroatoms.

Stable axial chirality in metal complexes bearing 4,4′-substituted BIPHEPs: Application to catalytic asymmetric carbon-carbon bond-forming reactions

Not only electronic but also steric effects of 4,4′-substituents in BIPHEP derivatives and metal (Pd, Pt, and Au) complexes are shown to influence the stability of the biphenyl single bond rotation. While electron-donating or sterically demanding substituents on the 4,4′-positions destabilize the axial chirality of BIPHEP derivatives, electron-withdrawing or sterically less demanding ones on the 4,4′-positions stabilize the axis chirality. Particularly, the axial chirality of palladium dichloride complexes bearing BIPHEP with t-Bu and CF3 substituents on the 4,4′-positions is most labile and stable, respectively (ΔG≠ = 29.22 and 30.49 kcal mol-1 at 300 K; t1/2 = 7 and 56 years at 300 K). These enantiopure dicationic BIPHEPPd complexes can be employed for catalytic enantioselective arylation, alkenylation, and ene reactions to give the corresponding products in good-to-excellent yields and enantioselectivities. Significantly, in the carbonyl-ene reaction of trifluoropyruvate with isobutene, the turnover frequency (TOF) reached 58200 h-1. The remarkable effects of 4,4′-substituents in BIPHEP derivatives can be employed as a guiding principle in the design of versatile and efficient ligands.

TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS

The present invention relates to tetracyclic indole derivatives of formula (I); wherein Ar, D1, D2, D3, D4, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical composi