4961-40-4 Usage
Description
Triethylenetetramine tetrahydrochloride is a chemical compound with the formula C6H12N4·4HCl. It is a white crystalline solid that is soluble in water and has a strong, irritating odor. TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE is a derivative of triethylenetetramine, which is a heterocyclic amine with four nitrogen atoms in a ring structure. The tetrahydrochloride salt form is commonly used due to its increased solubility and stability.
Uses
Used in Affinity Chromatography:
Triethylenetetramine tetrahydrochloride is used as a primary amine displacer in affinity chromatography. Affinity chromatography is a technique used to separate and purify specific molecules, such as proteins, based on their interactions with a specific ligand or target molecule. In this application, triethylenetetramine tetrahydrochloride serves to displace primary amines from their binding sites on the affinity matrix, allowing for the selective elution of the target molecule.
In the biotechnology and pharmaceutical industries, affinity chromatography is a valuable tool for the purification of proteins, enzymes, and other biomolecules. The use of triethylenetetramine tetrahydrochloride as a primary amine displacer enhances the efficiency and selectivity of the purification process, making it a useful component in the development and optimization of affinity chromatography systems.
Biochem/physiol Actions
Triethylenetetramine tetrahydrochloride induces apoptosis of acinar cells of the pancreas in male Fischer 344 rats.
Check Digit Verification of cas no
The CAS Registry Mumber 4961-40-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,6 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4961-40:
(6*4)+(5*9)+(4*6)+(3*1)+(2*4)+(1*0)=104
104 % 10 = 4
So 4961-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2/p+4
4961-40-4Relevant articles and documents
CRYSTALLINE FORM OF TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE AND ITS PHARMACEUTICAL USE
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Page/Page column 37, (2019/11/19)
The present invention describes a new crystalline form of triethylenetetramine tetrachloride which has improved room temperature stability over known forms and over the dichloride salt. The new crystalline form is characterised by having peaks in an XRPD spectrum at 22.9, 25.4, 25.8, 26.6, 34.6 and 35.3 ± 0.1°2Θ and Raman shifts 943, 1173, 1527 and 1612 ± 5 cm-1. The crystalline form of triethylenetetramine tetrachloride is useful in the treatment of Wilson's disease. Also disclosed is a method for preparing a crystalline form of triethylenetetramine tetrachloride comprising the addition of an anti- solvent to an aqueous solution of the compound.