5153-92-4Relevant articles and documents
Scalable synthesis of methyl ent-isocopalate and its derivatives
Hua, Si-Kai,Wang, Jing,Chen, Xi-Bo,Xu, Zhong-Yu,Zeng, Bu-Bing
, p. 1142 - 1144 (2011)
An efficient and convenient synthetic route was developed to prepare the tricycle diterpene intermediates 1-3 starting from commercially available (-)-sclareol. This improved approach involving four-step reactions provides large-scale (30-40 g) methyl ent-isocopalate in 61% overall yield, which could supply sufficient material for the synthesis of marine natural products containing tricyclic diterpenes.
Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene-Hopene Cyclases
Seitz, Miriam,Syrén, Per-Olof,Steiner, Lisa,Klebensberger, Janosch,Nestl, Bettina M.,Hauer, Bernhard
, p. 436 - 439 (2013/04/24)
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Catalytic epoxypolyene cyclization via radicals: A simple total synthesis of sclareol oxide and its 8-epimer
Gansaeuer, Andreas,Worgull, Dennis,Justicia, Jose
, p. 2151 - 2154 (2008/02/02)
A short synthesis of sclareol oxide from epoxyfarnesyl acetone in six steps is described. The strategy features a titanocene-catalyzed epoxypolyene cyclization for the construction of the carbocyclic core structure. The exo olefin formed during the termin