5317-32-8 Usage
Description
1-Piperazinepropanol is an organic compound with the molecular formula C6H14N2O. It is a colorless liquid at room temperature and is commonly used as a building block in the synthesis of various biologically active molecules.
Uses
Used in Pharmaceutical Industry:
1-Piperazinepropanol is used as a reactant for the preparation of biologically active molecules for various applications.
1-Piperazinepropanol is used as a reactant for the preparation of chloropyridazine piperazines, which serve as human rhinovirus (HRV-3) inhibitors. This application is crucial in the development of antiviral drugs to combat HRV-3 infections.
1-Piperazinepropanol is also used in the synthesis of arylbenzoylpyrrolidine derivatives, which exhibit Hsp90 inhibitory activity. Hsp90 (Heat shock protein 90) is a protein that plays a role in various cellular processes, and its inhibition can have therapeutic benefits in treating certain diseases.
Furthermore, 1-Piperazinepropanol is utilized in the preparation of pyrrolothienopyrazines, which act as novel serotonin-4 receptor antagonists. These compounds have potential applications in the treatment of various disorders related to serotonin regulation, such as gastrointestinal, cardiovascular, and central nervous system conditions.
Lastly, 1-Piperazinepropanol is used in the preparation of carbamate-functionalized 2,6-disubstituted N-(arylsulfonyl) piperidines. These compounds serve as conformationally restricted and orally active γ-secretase inhibitors, which are important in the development of drugs targeting Alzheimer's disease and other neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 5317-32-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,1 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5317-32:
(6*5)+(5*3)+(4*1)+(3*7)+(2*3)+(1*2)=78
78 % 10 = 8
So 5317-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N2O/c1-2-7(10)9-5-3-8-4-6-9/h7-8,10H,2-6H2,1H3
5317-32-8Relevant articles and documents
2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY
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Page/Page column 89-90; 91-92; 114, (2018/03/26)
Compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.
Method for producing N-alkylpiperazine
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Paragraph 0057, (2017/02/09)
PROBLEM TO BE SOLVED: To provide a method for producing N-alkyl piperazines in high yield by selectively alkylating one amino group.SOLUTION: In the method for producing N-alkyl piperazines, piperazines represented by general formula (1) are reacted with a specific alkylating agent in the presence of an acid. In the formula: R-Rare each independently a hydrogen atom, a methyl group, an ethyl group, a 3-8C linear alkyl group or the like, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group, a methoxy group, an ethoxy group, a phenyl group, a benzyl group, a 2-phenylethyl group, or the like.
PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION
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Paragraph 0046, (2013/06/27)
Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.