53324-38-2

Basic information

• Product Name: 4-BROMO-3-NITROANILINE
• Synonyms: 4-BROMO-3-NITROANILINE;4-BROMO-3-NITROANILINE 97%;4-Bromo-3-nitroaniline,97%;4-BroMo-3-nitroaniline, 97% 5GR;5-Amino-2-bromonitrobenzene;BenzenaMine,4-broMo-3-nitro-
• CAS NO: 53324-38-2
• Molecular Formula: C₆H₅BrN₂O₂
• Molecular Weight: 217.02
• Product Categories: API intermediates
• Mol File: 53324-38-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 128-132 °C
• Boiling Point: 299.663 °C at 760 mmHg
• Flash Point: 135.032 °C
• Appearance: Orange to dark brown/Crystalline Powder
• Density: 1.7917 (rough estimate)
• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.5150 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.87±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-3-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-NITROANILINE(53324-38-2)
• EPA Substance Registry System: 4-BROMO-3-NITROANILINE(53324-38-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 53324-38-2(Hazardous Substances Data)

Usage

Chemical Properties

ORANGE TO DARK BROWN CRYSTALLINE POWDER

InChI:InChI=1/C6H5BrN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2

Upstream product

• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 99-09-2 3-nitro-aniline 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 106-40-1 4-bromo-aniline 
• 67-66-3 chloroform 
• 40101-31-3 2-(4-bromophenyl)isoindoline-1,3-dione 
• 584-48-5 2,4-dinitrobromobenzene 

Downstream Products

• 1312610-95-9 C₃₉H₄₇N₇O₄ 
• 1312610-94-8 C₂₇H₃₅B₂NO₄ 
• 1312610-93-7 C₁₅H₁₁Br₂N 
• 713512-18-6 2-bromo-5-iodonitrobenzene 
• 1036751-06-0 N-(4-bromo-3-nitrophenyl)-5-chloro-1H-indole-2-carboxamide 
• 928847-00-1 3-nitro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine 
• 51686-78-3 2,4-dibromonitrobenzene 
• 19230-27-4 2-chloro-1,3-dibromobenzene 
• 13402-32-9 1,3-dibromo-2-nitrobenzene 
• 1630-08-6 1,3,5-trinitrobenzenediamine 
• 608-30-0 2,6-dibromoaniline 
• 608-21-9 1,2,3-tribromobenzene 
• 13506-78-0 1,3-dibromo-2,4,6-trinitrobenzene 
• 82-71-3 styphnic acid 

Relevant articles and documents

Cu-mediated selective bromination of aniline derivatives and preliminary mechanism study

A simple and efficient bromination of aniline, aniline derivatives, and analogs have been developed. Forty three examples were given and the highest yield reached was 98%. Different substrates including substituted aniline, pyridin-amine, N-substituted aniline, N,N-disubstituted aniline, N-phenyl-amide, N-phenyl-sulfonamide, and nitrogen-containing heterocycles were all reactive and selectively generated desired bromo-products. The method can be applied to synthesize drug intermediate and quinoxaline derivatives.

Electrophilic bromination of meta-substituted anilines with N-bromosuccinimide: Regioselectivity and solvent effect

N-Bromosuccinimide-mediated electrophilic aromatic bromination of a series of anilines substituted with an electron-with-drawing group in the meta position was investigated. The regioselectivity of the reaction is markedly dependent on the polarity of the solvent and the bromination reaction can be tuned by appropriate selection of the reaction medium. Georg Thieme Verlag Stuttgart.

AI203/MeS03H (AMA) as a novel heterogeneous system for the nitration of aromatic compounds by magnesium nitrate hexahydrate

Mg(NO3)2-6H2O was an efficient nitrating agent in the presence of a mixture of AI2O3/MeSO 3H (AMA) as a novel heterogeneous system for the nitration of aromatic compounds without use of any organic solvents and with high selectivity. The reaction proceeds at room temperature for the nitration of highly reactive aromatic compounds such as phenols and anilines.