5422-01-5Relevant articles and documents
Direct transformation of aryl 2-pyridyl esters to secondary benzylic alcohols by nickel relay catalysis
Wu, Xianqing,Li, Xiaobin,Huang, Wenyi,Wang, Yun,Xu, Hui,Cai, Liangzhen,Qu, Jingping,Chen, Yifeng
supporting information, p. 2453 - 2458 (2019/03/29)
A direct transformation of aryl esters to secondary benzylic alcohols via tandem Ni-catalyzed cross-coupling reactions of aromatic 2-pyridyl esters with alkyl zinc reagents and carbonyl group reduction by Ni-H species is achieved. Preliminary mechanistic studies reveal that the Ni-H species is generated in situ via β-hydride elimination of the Negishi reagents. The reaction is catalyzed by bench-stable nickel salts under mild conditions with wide functional group tolerance.
Aromatic amides as potentiators of bioefficacy of anti-infective drugs
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Page/Page column 10, (2008/06/13)
The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.
Regioselective annulation of 5-(1-alkenyl)- and 5-vinyl-1,3-benzodioxoles with 3-chloro-3-cyclobutene-1,2-dione. Synthesis of 3,4-dihydrocyclobuta[5,6]-naphtho[2,3-d][1,3]dioxole-1,2-diones and cyclobuta[5,6]naphtho[2,3-d][1,3]dioxole-1,2-diones
Schmidt,Kircher,Kunz,Wahl,Hendriok
, p. 3890 - 3894 (2007/10/02)
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