55578-14-8

Basic information

• Product Name: Benzenemethanamine, N-(1-methylethyl)-N-(phenylmethyl)-
• Synonyms: N,N-dibenzylisoprpopylamine;2-Propanamine,N,N-dibenzyl;dibenzyl-isopropyl-amine;N,N-Dibenzyl-2-propanamine;Dibenzyl-isopropyl-amin;N,N-dibenzylisopropylamine
• CAS NO: 55578-14-8
• Molecular Formula: C17H21N
• Molecular Weight: 239.36
• Mol File: 55578-14-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 317.4±11.0 °C(Predicted)
• Density: 0.996±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenemethanamine, N-(1-methylethyl)-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-(1-methylethyl)-N-(phenylmethyl)-(55578-14-8)
• EPA Substance Registry System: Benzenemethanamine, N-(1-methylethyl)-N-(phenylmethyl)-(55578-14-8)

Safety Data

• Hazardous Substances Data: 55578-14-8(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 75-31-0 isopropylamine 
• 102-97-6 Benzyl-isopropyl-amin 
• 105680-00-0 N-benzyl-N-isopropylbenzamide 
• 67-64-1 acetone 
• 103-49-1 dibenzylamine 
• 60479-65-4 (S)-2-(N,N-dibenzylamino)-1-propanol 
• 100-51-6 benzyl alcohol 
• 780-25-6 N-benzylidene benzylamine 
• 618-32-6 Benzoyl bromide 
• 5440-69-7 N-isopropylbenzamide 
• 52742-32-2 N,N-dibenzyl-O-benzoylhydroxylamine 
• 625-81-0 diisopropyl zinc 

Downstream Products

• 5440-69-7 N-isopropylbenzamide 

Relevant articles and documents

Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3as a reductant

Herein, we report the first example of efficient reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a catalyst and a reductant under mild conditions, affording various tertiary and secondary amines in excellent yields. A mechanistic study indicates that BH3N(C2H5)3 plays a dual function role of promoting imine and iminium formation and serving as a reductant in reductive amination. This journal is

The synthesis of sterically hindered amines by a direct reductive amination of ketones

An atom-economical methodology for the synthesis of sterically hindered tertiary amines was developed, which is based on complementary Rh- and Ru-catalyzed direct reductive amination of ketones with primary and secondary amines using carbon monoxide as a deoxygenating agent.

Nonlinear taft polar free energy relationship: Reactions of N-substituted benzyl amines with benzyl bromide in methanol

The rates of reactions of N-substituted benzyl amines with benzyl bromide were measured using a conductivity technique in methanol medium. The reaction followed a total second-order path. The end product of the reaction is identified as dibenzyl alkyl amine (C6H5CH 2N(R)CH2C6H5). The rates increased with a decrease in the electron-donating capacity or with an increase in the Taft σ* value of electron-donating alkyl substituents (R) such as t-butyl (σ* = -0.3), i-propyl (σ* = -0.19), n-butyl (σ* = -0.13), and ethyl (σ* = -0.1) on nitrogen of the amine until the Taft σ* value becomes zero for the methyl group (σ CH 3* = 0.00), and then the rates decreased with an increase in the electron-withdrawing capacity or with an increase in the Taft σ* value of electron-withdrawing substituents (R) such H and C6H 5 (σH* = 0.49 and σC6H5= 0.6). The locus of the Taft polar free energy relationship has a maximum near the point for N-methyl benzyl amine, showing that there is a sharp change in the rate-determining step. A mechanism involving formation of an SN2-type transition state between the amine nucleophiles and the benzyl bromide and its subsequent decomposition is proposed. Activation parameters were calculated and are discussed.