59010-46-7Relevant articles and documents
Synthesis of (+/-)-hamigeran B, (-)-hamigeran B, and (+/-)-1-epi-hamigeran B: use of bulky silyl groups to protect a benzylic carbon-oxygen bond from hydrogenolysis.
Clive, Derrick L J,Wang, Jian
, p. 2773 - 2784 (2007/10/03)
Enone 42 was converted into diene 56, which was then subjected to hydrogenation. Use of the tert-butyldimethylsiloxy groups enforces facial selectivity and protects the C(5) oxygen from hydrogenolysis. The resulting product (55) is easily converted into hamigeran B (1), a marine natural product with powerful activity against herpes and polio viruses. Optically pure enone 73 was made by use of a Meyers' auxiliary and converted into (-)-hamigeran B with the natural absolute configuration.
Synthesis of rac-Cinera-5,7,11-trien-9-one
Bohlmann, Ferdinand,Krueger, Martin
, p. 560 - 565 (2007/10/02)
The spiro trienone 22 isolated from a Cineraria species has been synthesized as racemate by intramolecular alkylation starting with 5-isopropyl-3-methylphenol via a suitable phenol substituted in position 2.This compound gave no Diels-Alder reaction with