603-78-1 Usage
Description
2,3-Dibromobenzoic acid is an organic compound characterized by the presence of two bromine atoms at the 2nd and 3rd positions on a benzene ring, with a carboxylic acid group attached. It is known for its potential applications in various chemical and pharmaceutical processes due to its unique structure and properties.
Uses
Used in Pharmaceutical Industry:
2,3-Dibromobenzoic acid is used as a key intermediate in the synthesis of acylhydrazone-based inhibitors of fungal sphingolipid synthesis. These inhibitors are being developed as next-generation antifungal agents, offering new treatment options for combating fungal infections.
In the synthesis process, 2,3-dibromobenzoic acid serves as a starting material, which can be further modified and combined with other chemical entities to create novel antifungal compounds. These compounds target the fungal sphingolipid synthesis pathway, which is essential for the growth and survival of fungi. By inhibiting this pathway, the acylhydrazone-based inhibitors can effectively control and eliminate fungal infections, providing a promising alternative to existing antifungal drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 603-78-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 603-78:
(5*6)+(4*0)+(3*3)+(2*7)+(1*8)=61
61 % 10 = 1
So 603-78-1 is a valid CAS Registry Number.
603-78-1Relevant articles and documents
Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acids
Menzel, Karsten,Dimichele, Lisa,Mills, Paul,Frantz, Doug E.,Nelson, Todd D.,Kress, Michael H.
, p. 1948 - 1952 (2008/02/08)
Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes. Eleven examples are given. Georg Thieme Verlag Stuttgart.
Ortho-metalation of unprotected 3-bromo and 3-chlorobenzoic acids with hindered lithium dialkylamides
Gohier, Frederic,Mortier, Jacques
, p. 2030 - 2033 (2007/10/03)
Upon treatment of 3-chloro/bromobenzoic acids with hindered lithium dialkylamides (LDA or LTMP) at -50 °C, lithium 3-chloro/bromo-2-lithiobenzoates are generated. These dianions can be trapped as such to afford after electrophilic quenching a variety of s
Copper(I) Catalysed Replacement of Bromine by Chloride Ion in Bromobenzoic Acids
Liedholm, Brita
, p. 713 - 716 (2007/10/02)
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