60731-46-6

Basic information

• Product Name: Elcatonin
• Synonyms: (aminosubericacid1,7)-eelcalcitonin;1-butanoicacid-26-l-asparticacid-27-l-valine-7-dicarbacalcitonin(salmon);29-l-alanine-;(L-ALPHA-AMINOSUBERIC ACID1,7)-CALCITONIN (EEL);ELCATONIN;ELCATONIN (EEL);(DES CYS1,CYCLO (SER2-ASU7))-CALCITONIN (EEL) ACETATE SALT;CYCLO(-SER-ASN-LEU-SER-THR-ASU)-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASP-VAL-GLY-ALA-GLY-THR-PRO-NH2
• CAS NO: 60731-46-6
• Molecular Formula: C148H244N42O47
• Molecular Weight: 3363.77
• EINECS: 262-393-7
• Mol File: 60731-46-6.mol
• Article Data: 0

Chemical Properties

• Appearance: White powder.
• Density: 1.49±0.1 g/cm3(Predicted)
• Refractive Index: 1.658
• Storage Temp.: -15°C
• CAS DataBase Reference: Elcatonin(CAS DataBase Reference)
• NIST Chemistry Reference: Elcatonin(60731-46-6)
• EPA Substance Registry System: Elcatonin(60731-46-6)

Safety Data

• RTECS: HS9270000
• Hazardous Substances Data: 60731-46-6(Hazardous Substances Data)

Usage

Description

Elcatonin, with the molecular formula C148H244N42O47, is a single, non-glycosylated polypeptide chain composed of 31 amino acids. It is a derivative of calcitonin and functions as an anti-parathyroid agent. Elcatonin is primarily utilized for alleviating and eliminating pain associated with osteoporosis. It exerts several physiological effects, such as inhibiting bone absorption and autolysis, which results in reduced blood calcium levels; preventing the dissolution and transfer of bone salts, thereby promoting the excretion of calcium and phosphorus in urine; and inhibiting the reabsorption of calcium, phosphorus, and sodium by renal tubules.

Uses

Used in Osteoporosis Treatment:
Elcatonin is used as a therapeutic agent for osteoporosis, helping to mitigate and eliminate the pain caused by this condition. Its ability to inhibit bone absorption and autolysis contributes to the reduction of blood calcium levels, making it a valuable treatment option for osteoporosis patients.
Used in Hypercalcemia Management:
Elcatonin serves as a management tool for hypercalcemia, a condition characterized by abnormally high levels of calcium in the blood. By inhibiting the dissolution and transfer of bone salts, it promotes the excretion of calcium and phosphorus in urine, thus helping to regulate blood calcium levels.
Used in Paget’s Disease Therapy:
Elcatonin is utilized in the therapy for Paget’s disease, a chronic bone disorder that leads to bones becoming painful, misshapen, and fragile. Its inhibitory effects on bone absorption and the reabsorption of calcium, phosphorus, and sodium by renal tubules make it a beneficial treatment for managing the symptoms and progression of Paget’s disease.

References

http://www.prospecbio.com/Elcatonin_7_42/ https://en.wikipedia.org/wiki/Elcatonin

Hazard

A poison by ingestion.

Safety Profile

experimental neoplastigenic data by skin

InChI:InChI=1/C148H244N42O47/c1-69(2)52-92(178-142(231)115(75(13)14)185-128(217)87-30-21-20-22-36-113(208)237-67-84(151)122(211)172-98(59-107(154)200)136(225)176-96(56-73(9)10)134(223)182-102(66-192)139(228)188-116(77(16)193)143(232)171-87)123(212)161-63-109(202)165-85(31-23-25-47-149)124(213)173-95(55-72(7)8)133(222)181-101(65-191)138(227)169-89(41-44-105(152)198)126(215)167-91(43-46-111(204)205)127(216)175-94(54-71(5)6)132(221)177-97(58-82-61-158-68-163-82)135(224)166-86(32-24-26-48-150)125(214)174-93(53-70(3)4)131(220)168-90(42-45-106(153)199)130(219)187-118(79(18)195)145(234)180-100(57-81-37-39-83(197)40-38-81)146(235)190-51-29-35-104(190)140(229)170-88(33-27-49-159-148(156)157)129(218)186-117(78(17)194)144(233)179-99(60-112(206)207)137(226)184-114(74(11)12)141(230)162-62-108(201)164-76(15)121(210)160-64-110(203)183-119(80(19)196)147(236)189-50-28-34-103(189)120(155)209/h37-40,61,68-80,84-104,114-119,191-197H,20-36,41-60,62-67,149-151H2,1-19H3,(H2,152,198)(H2,153,199)(H2,154,200)(H2,155,209)(H,158,163)(H,160,21