622-50-4

Basic information

• Product Name: N-(4-Iodophenyl)acetamide
• Synonyms: 4’-iodo-acetanilid;Acetamide, N-(4-iodophenyl)-;Acetanilide, 4'-iodo-;n-(4-iodophenyl)-acetamid;n-(4-iodophenyl)acetamide;p-Iodoacetanilide;4'-IODOACETANILIDE;4-IODOACETANILIDE
• CAS NO: 622-50-4
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.06
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;API intermediates;Anilines, Amides & Amines;Iodine Compounds
• Mol File: 622-50-4.mol
• Article Data: 115

Chemical Properties

• Melting Point: 182.0 to 187.0 °C
• Boiling Point: 180°C (rough estimate)
• Appearance: Bluish-gray to purple/Powder
• Density: 1.7396 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 14.38±0.70(Predicted)
• Water Solubility: 182.7mg/L(25 oC)
• CAS DataBase Reference: N-(4-Iodophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Iodophenyl)acetamide(622-50-4)
• EPA Substance Registry System: N-(4-Iodophenyl)acetamide(622-50-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: AE4285000
• Hazardous Substances Data: 622-50-4(Hazardous Substances Data)

Usage

Chemical Properties

Bluish-grey to purple powder

Upstream product

• 62-53-3 aniline 
• 463-51-4 Ketene 
• 540-37-4 p-aminoiodobenzene 
• 108-24-7 acetic anhydride 
• 110-86-1 pyridine 
• 13114-95-9 1-(4-iodophenyl)urea 
• 2033-24-1 cycl-isopropylidene malonate 
• 75-05-8 acetonitrile 
• 159217-89-7 N-Boc-4-iodoaniline 
• 60-35-5 acetamide 
• 624-38-4 para-diiodobenzene 
• 59-88-1 phenylhydrazine hydrochloride 
• 10387-40-3 potassium thioacetate 
• 67-64-1 acetone 

Downstream Products

• 93298-22-7 N-{4-[1-(4-Acetylamino-phenyl)-3-oxo-butyl]-phenyl}-acetamide 
• 104581-31-9 N-[4-(3-Hydroxy-3-methyl-but-1-ynyl)-phenyl]-acetamide 
• 106865-18-3 (4-acetamidophenyl)diphenylphosphine 
• 103-84-4 Acetanilid 
• 540-37-4 p-aminoiodobenzene 
• 57103-11-4 9-((4-acetamido)phenyl)carbazole 
• 214360-60-8 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 62404-59-5 4-(N-acetyl-N-methylamino)iodobenzene 
• 1338574-35-8 6-[(4-diphenylaminophenyl)ethyn-1-yl]benzothiazole-2-carbaldehyde 
• 1338574-38-1 2-{{6-[(4-diphenylaminophenyl)ethyn-1-yl]benzothiazol-2-yl}methylene}malononitrile 

Relevant articles and documents

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted sele

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

NCBSI/KI: A Reagent System for Iodination of Aromatics through in Situ Generation of I-Cl

In situ iodine monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system has been developed. The NCBSI reagent requires no activation due to longer bond length, lower bond dissociation energy, and higher absolute charge density on nitrogen. The system is adequate for mono- and diiodination of a wide range of moderate to highly activated arenes with good yield and purity. Moreover, the precursor N-(benzenesulfonyl)benzenesulfonamide can be recovered and transformed to NCBSI, making the protocol eco-friendly and cost-effective.