63958-90-7

Basic information

• Product Name: SERUM THYMIC FACTOR
• Synonyms: 5-Oxo-L-Pro-L-Ala-L-Lys-L-Ser-L-Gln-Gly-Gly-L-Ser-L-Asn-OH;pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn;STF, SeruM ThyMic Factor, ThyMulin;Serum thymic factor (porcine);Thymic serum factor;Thymic serum factor (pig);L-Asparagine,5-oxo-L-prolyl-L-alanyl-L-lysyl-L-seryl-L-glutaminylglycylglycyl-L-seryl-;Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH trifluoroacetate salt
• CAS NO: 63958-90-7
• Molecular Formula: C₃₃H₅₄N₁₂O₁₅
• Molecular Weight: 858.85
• Product Categories: Peptide
• Mol File: 63958-90-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 1658.9 °C at 760 mmHg
• Flash Point: 957.1 °C
• Appearance: white/
• Density: 1.417 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: −20°C
• Solubility: deionized water: soluble
• PKA: 3.08±0.10(Predicted)
• CAS DataBase Reference: SERUM THYMIC FACTOR(CAS DataBase Reference)
• NIST Chemistry Reference: SERUM THYMIC FACTOR(63958-90-7)
• EPA Substance Registry System: SERUM THYMIC FACTOR(63958-90-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 63958-90-7(Hazardous Substances Data)

Usage

General Description

Serum thymic factor (STF) is a naturally occurring mixture of polypeptides derived from calf thymus glands. It plays a crucial role in regulating the function of the immune system, specifically in the development and maintenance of T lymphocytes. STF has been shown to enhance the production and activity of T cells, which are vital for the body's defense against infections and diseases. Additionally, it has been explored for its potential therapeutic properties in treating conditions such as autoimmune diseases, cancer, and immunodeficiency disorders. Research on STF continues to uncover its potential in modulating immune responses and supporting overall immune function.

InChI:InChI=1/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1

Synthetic route

pyroglutamyl-alanyl-Nε-benzyloxycarbonyllysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester (110523-43-8) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
With hydrogen; palladium In water; acetic acid for 12h; Ambient temperature;	84%

Z-Pyr-Ala-Lys(Z)-Ser-Asn-Gly-Gly-Ser-Gln-ONb → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
With hydrogen; palladium on activated charcoal In acetic acid for 24h;	52%

Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt (16948-04-2) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 6 steps 1: 94 percent / HOBT, WSCl, NMM / tetrahydrofuran / 16 h / 4 °C 2: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight 3: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C 4: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 6: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyllysyl-serine methyl ester (84983-67-5) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C 2: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 4: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme
Multi-step reaction with 5 steps 1: 88 percent / NaOH / methanol; H2O / 0.5 h / Ambient temperature 2: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 3: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 4: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 5: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

Boc-Ser-Gln-ONb → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight 2: 1.) TFA, anisole 2.) NMM / 1.) room temperature, 20 min 2.) DMF, room temperature, 18 h. 4: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Boc-Gly-Gly-Ser-Gln-ONb → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) TFA, anisole 2.) NMM / 1.) room temperature, 20 min 2.) DMF, room temperature, 18 h. 3: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Z-Pyr-Ala-Lys(Z)-Ser-OMe (84983-68-6) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 3: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Z-Pyr-Ala-Lys(Z)-Ser-NHNH2 (84983-69-7) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 2 steps 2: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Boc-Asn-Gly-Gly-Ser-Gln-ONb → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 2 steps 2: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Boc-Lys(Z)-Ser-OMe (84983-66-4) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 5 steps 1: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight 2: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C 3: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 5: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

alanyl-Nε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride (110523-42-7) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 2: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester (110523-36-9) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 9 steps 1: 95 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature 2: 40 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1) O deg C, 2 h, 2) room temperature, 8 h 3: 96 percent / hydrochloric acid / acetic acid; H2O / 1 h / Ambient temperature 4: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h 5: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature 6: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 7: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 8: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 9: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

Nα-2-nitrobenzenesulfenyl-Nε-benzyloxycarbonyllysyl-serine methyl ester → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 7 steps 1: 80 percent / HCl / acetic acid; methanol / 0.75 h / Ambient temperature 2: 91 percent / N-ethylpiperidine / dimethylformamide / 12 h / Ambient temperature 3: 88 percent / NaOH / methanol; H2O / 0.5 h / Ambient temperature 4: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 5: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 6: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 7: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

seryl-asparagine 4-nitrobenzyl ester hydrobromide (110523-37-0) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 8 steps 1: 40 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1) O deg C, 2 h, 2) room temperature, 8 h 2: 96 percent / hydrochloric acid / acetic acid; H2O / 1 h / Ambient temperature 3: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h 4: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature 5: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 6: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 7: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 8: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

Nε-benzyloxycarbonyllysyl-serine methyl ester hydrochloride (110523-34-7) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 6 steps 1: 91 percent / N-ethylpiperidine / dimethylformamide / 12 h / Ambient temperature 2: 88 percent / NaOH / methanol; H2O / 0.5 h / Ambient temperature 3: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 4: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 5: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 6: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

tert.-butyloxycarbonylglycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester (110523-38-1) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 7 steps 1: 96 percent / hydrochloric acid / acetic acid; H2O / 1 h / Ambient temperature 2: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h 3: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature 4: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 5: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 6: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 7: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrobromide (740049-43-8) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 4 steps 1: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 2: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 3: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 4: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride (110523-39-2) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 6 steps 1: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h 2: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature 3: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 4: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 5: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 6: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

benzyloxycarbonylglutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester (76495-99-3) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 5 steps 1: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature 2: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 3: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 4: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 5: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

Nα-2-nitrobenzenesulfenyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt (68739-54-8) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 8 steps 1: 95 percent / N,N'-dicyclohexylcarbodiimide / dimethylformamide / 3 h / Ambient temperature 2: 80 percent / HCl / acetic acid; methanol / 0.75 h / Ambient temperature 3: 91 percent / N-ethylpiperidine / dimethylformamide / 12 h / Ambient temperature 4: 88 percent / NaOH / methanol; H2O / 0.5 h / Ambient temperature 5: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 6: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 7: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 8: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester (110523-41-6) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 2: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 3: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyllysyl-serine (110523-35-8) → pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine (63958-90-7)

Conditions

Yield

Multi-step reaction with 4 steps 1: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 2: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 3: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 4: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

Upstream product

• 110523-35-8 tert.-butyloxycarbonylalanyl-N^ε-benzyloxycarbonyllysyl-serine 
• 110523-41-6 tert.-butyloxycarbonylalanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester 
• 68739-54-8 N^α-2-nitrobenzenesulfenyl-N^ε-benzyloxycarbonyllysine dicyclohexylammonium salt 
• 76495-99-3 benzyloxycarbonylglutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester 
• 110523-39-2 glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride 
• 740049-43-8 glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrobromide 
• 110523-38-1 tert.-butyloxycarbonylglycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester 
• 110523-34-7 N^ε-benzyloxycarbonyllysyl-serine methyl ester hydrochloride 
• 110523-37-0 seryl-asparagine 4-nitrobenzyl ester hydrobromide 
• 110523-36-9 benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester 
• 110523-42-7 alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride 
• 84983-66-4 Boc-Lys(Z)-Ser-OMe 
• 84983-69-7 Z-Pyr-Ala-Lys(Z)-Ser-NHNH₂ 
• 84983-68-6 Z-Pyr-Ala-Lys(Z)-Ser-OMe 

Relevant articles and documents

SYNTHESIS OF BLOOD SERUM THYMIC FACTOR AND ITS ANALOGS

The blood serum thymic factor (FTS) and its two analogs (desGlp1)-FTS and (Gln1)-FTS were synthesized by a novel procedure.The biological activity of these compounds was assayed by the E-rosette test.The activity of (desGlp1)-FTS is decreased and (Gln1)-FTS shows an inhibitory effect.