688-84-6Relevant articles and documents
Do ion tethered functional groups affect IL solvent properties? The case of sulfoxides and sulfones
Sharma, Nawal K.,Tickell, Morgan D.,Anderson, Jared L.,Kaar, Joel,Pino, Veronica,Wicker, Benjamin F.,Armstrong, Daniel W.,Davis Jr., James H.,Russell, Alan J.
, p. 646 - 648 (2006)
The covalent incorporation of functional groups - specifically sulfoxide and sulfone - into the cation of imidazolium ionic liquids leads to significant, quantifiable changes in solvent parameters which in turn have important effects on the bulk properties of the materials. The Royal Society of Chemistry 2006.
High-contrast fluorescence imaging of tumors in vivo using nanoparticles of amphiphilic brush-like copolymers produced by ROMP
Miki, Koji,Kimura, Akinori,Oride, Kazuaki,Kuramochi, Yoshiaki,Matsuoka, Hideki,Harada, Hiroshi,Hiraoka, Masahiro,Ohe, Kouichi
supporting information; experimental part, p. 6567 - 6570 (2011/09/15)
Nanoparticles at work: High-contrast tumor imaging of mice was performed by using copolymers with hydrophobic and hydrophilic polymer brushes that form cross-linked assemblies and show a highly stable core surface in aqueous media (see picture). Cyclic RGD peptides and glucosamine moieties were localized on the surface of the assemblies and acted as targeting agents (TA) that enhanced the accumulation of the assemblies in tumor tissues. Copyright
Impact of ionic liquid physical properties on lipase activity and stability
Kaar, Joel L.,Jesionowski, Anita M.,Berberich, Jason A.,Moulton, Roger,Russell, Alan J.
, p. 4125 - 4131 (2007/10/03)
Lipase activity and stability was investigated in dialkylimidazolium and pyrrolidinium-based ionic liquids with a variety of anions including hexafluorophosphate, acetate, nitrate, methanesulfonate, trifluoroacetate, and trifluoromethylsulfonate. The initial rate of lipase-catalyzed transesterification of methyl methacrylate in these ionic liquids and several organic solvents was examined as well as the polytransesterification of divinyl adipate and 1,4-butanediol. Free lipase (Candida rugosa) catalyzed the transesterification of methyl methacrylate in 1-butyl-3-methylimidazolium hexafluorophosphate at a rate 1.5 times greater than in hexane. However, no detectable activity was observed in all the hydrophilic ionic liquids studied. Methods of enzyme stabilization including adsorption, PEG-modification, and immobilization in polyurethane foam were ineffective in improving enzymatic activity in the hydrophilic ionic liquids. Polytransesterifications performed in 1-butyl-3-methylimidazolium hexafluorophosphate using Novozym 435 produced polyesters with weight average molecular weights limited to 2900 Da due to precipitation of the polymer. Solvatochromic studies and partition coefficient measurements suggest that ionic liquids are more polar and hydrophilic than organic solvents such as hexane, acetonitrile, and tetrahydrofuran. Stability studies indicate that lipases exhibit greater stability in ionic liquids than in organic solvents including hexane.