76782-82-6Relevant articles and documents
SuFEx on the Surface: A Flexible Platform for Postpolymerization Modification of Polymer Brushes
Yatvin, Jeremy,Brooks, Karson,Locklin, Jason
, p. 13370 - 13373 (2015)
Polymer brushes present a unique architecture for tailoring surface functionalities due to their distinctive physicochemical properties. However, the polymerization chemistries used to grow brushes place limitations on the monomers that can be grown direc
Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids
Shchegravina, Ekaterina S.,Maleev, Alexander A.,Ignatov, Stanislav K.,Gracheva, Iuliia A.,Stein, Andreas,Schmalz, Hans-Günther,Gavryushin, Andrey E.,Zubareva, Anastasiya A.,Svirshchevskaya, Elena V.,Fedorov, Alexey Yu.
, p. 51 - 60 (2017)
Two novel indole-containing allocolchicinoids were prepared from naturally occurring colchicine exploiting the Curtius rearrangement and tandem Sonogashira coupling/Pd-catalyzed cyclization as the key transformations. Their cytotoxic properties, apoptosis-inducing activity, tubulin assembly inhibition and short-time cytotoxic effects were investigated. Compound 7 demonstrated the most pronounced anti-cancer activity: IC50 1 nM, cell cycle arrest in the G2/M phase, 25% apoptosis induction, as well as lower destructive short-time effects on HT-29 cell line in comparison with colchicine. Docking studies for prepared indole-derived allocolchicine analogues were carried out.
Reverse Brook rearrangement of 2-alkynyl trialkylsilyl ether. Synthesis of optically active (1-hydroxy-2-alkynyl)trialkylsilane
Sakaguchi,Fujita,Suzuki,Higashino,Ohfune
, p. 6589 - 6592 (2000)
A new method for the synthesis of optically active α-hydroxyalkynylsilane 3 is described. The key step of the conversion to 3 was the use of the reverse Brook rearrangement of the 2-alkynyl silyl ether 2. (C) 2000 Elsevier Science Ltd.
Stereoselective formation of 1,4-dialkoxy-1,3-dienes from propargyl ethers and molybdenum carbene complexes
Harvey,Neil
, p. 2145 - 2150 (1993)
Under mild conditions 1,4-dialkoxy-1,3-butadienes can be smoothly prepared with a high level of stereoselectivity by thermolysis of molybdenum carbene complexes in the presence of propargyl ethers.
COMPOUNDS AND METHODS OF USE
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Page/Page column 220-221, (2022/03/09)
Disclosed are heterocyclic compounds or their pharmaceutically acceptable salts with ferroptosis-inducing activity, Those compounds or their pharmaceutically acceptable salts can be used to treat cancer.
PROBE FOR DETECTING CARBAPENEM-RESISTANT BACTERIA AND USE THEREOF
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Paragraph 0085; 0096-0098, (2021/09/10)
The present disclosure relates to a compound represented by Chemical Formula 1, a probe for detecting antibiotic-resistant bacteria, which includes the compound, a composition containing the compound, a kit including the compound and a method for detectin
Regio-divergent nickel catalysis: intramolecular [4+2] and [2+2] cycloaddition reactions between vinylallenes and alkynes
Arai, Shigeru,Inagaki, Saki,Nakajima, Masaya,Nishida, Atsushi
supporting information, p. 11268 - 11271 (2021/11/03)
Vinylallenes have been recognized as versatile C2 and C4 components for nickel-catalyzed intramolecular [4+2] and [2+2] cycloadditions. The former reaction was promoted by a Ni(0) complex (up to quantitative yield), and a Ni(ii) salt was a key species for