83349-37-5 Usage
Description
25(R)-Hydroxyprotopanaxadiol is a natural compound derived from the roots of Panax ginseng, belonging to the class of triterpenoid saponins. It exhibits various biological activities, such as anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties, and is known for its immune system modulation and antioxidant effects.
Used in Pharmaceutical Industry:
25(R)-Hydroxyprotopanaxadiol is used as a therapeutic agent for its potential applications in treating conditions such as cancer, cardiovascular diseases, and neurodegenerative disorders due to its diverse biological activities and promising potential in medicinal chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 83349-37-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,3,4 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 83349-37:
(7*8)+(6*3)+(5*3)+(4*4)+(3*9)+(2*3)+(1*7)=145
145 % 10 = 5
So 83349-37-5 is a valid CAS Registry Number.
InChI:InChI=1/C30H54O4/c1-25(2,33)13-9-14-30(8,34)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-34H,9-18H2,1-8H3/t19-,20+,21-,22+,23-,24-,27-,28+,29+,30+/m0/s1
83349-37-5Relevant articles and documents
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives
Zhang, Yumeng,Yuan, Weihui,Wang, Xude,Zhang, Hongyu,Sun, Yuanyuan,Zhang, Xiaoshu,Zhao, Yuqing
, p. 1910 - 1919 (2018/11/24)
Panaxadiol (PD), a diol-type ginseng saponin, with a dammarane skeleton plays a potential role in the apoptosis of tumor cells. In this study, 28 oxidation and nitrogen hybrid derivatives of PD were synthesized, of which 20 were novel compounds. All the obtained compounds were screened for their cytotoxic activity in six cell lines. As compared with the positive control, some compounds showed better anti-proliferative activities while having much weaker effect on the growth of normal cells. Among them, ring-A fused pyrazoline of PD (1j) displayed impressive cytotoxic activity with IC50 9.62 ± 1.34, 11.65 ± 1.71, and 13.45 ± 1.60 μM against A549, HeLa and 8901 cell lines, respectively. Additionally, compound 2f exhibited the most potent activity with an IC50 value of 8.93 ± 1.11 μM against cell line A549. Therefore, our results indicated that 1j and 2f can be promising lead candidates for further studies.
