864244-98-4

Basic information

• Product Name: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine
• Synonyms: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine;4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(WXC01437)
• CAS NO: 864244-98-4
• Molecular Formula: C₁₂H₁₁N₃O₃
• Molecular Weight: 245.23404
• Mol File: 864244-98-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 408.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• PKA: 6.54±0.11(Predicted)
• CAS DataBase Reference: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(864244-98-4)
• EPA Substance Registry System: 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine(864244-98-4)

Safety Data

• Hazardous Substances Data: 864244-98-4(Hazardous Substances Data)

Usage

Description

4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine is a pyridinamine derivative with a molecular formula of C12H11N3O3. It features a nitrophenyl group attached to the pyridine ring, making it a valuable building block in the synthesis of pharmaceutical compounds, agrochemicals, and materials science applications, such as organic semiconductors and dyes.

Uses

Used in Pharmaceutical Industry:
4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to inhibit specific biological processes, making it a promising candidate for the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine is utilized as a precursor in the production of pesticides. Its ability to interfere with biological pathways makes it a potential component in creating effective pest control solutions.
Used in Materials Science:
4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine is used as a component in the development of organic semiconductors and dyes. Its chemical properties contribute to the creation of innovative materials with potential applications in various fields.
It is crucial to handle 4-(2-Methyl-4-Nitrophenoxy)Pyridin-2-Amine with care and follow proper safety protocols due to its potential hazards.

Upstream product

• 19798-80-2 2-Amino-4-chloropyridine 
• 99-53-6 2-methyl-4-nitrophenol 
• 99586-65-9 4-chloropicolinamide 
• 98-98-6 2-Picolinic acid 
• 202216-99-7 4-chloro-2-pyridinamine hydrochloride 
• 455-88-9 5-nitro-2-fluorotoluene 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 33631-05-9 2-amino-4-hydroxypyridine 
• 65370-42-5 4-chloro-2-nitropyridine 
• 937263-40-6 tert-butyl 4-(2-methyl-4-nitrophenoxy)pyridin-2-ylcarbamate 

Downstream Products

• 937263-41-7 7-(2-methyl-4-nitrophenoxy)imidazo [1,2-a]pyridine 
• 937263-44-0 7-(2-methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a] pyridine 
• 937263-71-3 4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylaniline 
• 937263-43-9 tucatinib 
• 1229607-60-6 2-methoxy-N-(4-(2-methyl-4-nitrophenoxy)pyridin-2-yl)acetamide 
• 864245-03-4 1-(3-diethylaminopropyl)-3-[4-(2-methyl-4-nitrophenoxy)pyridin-2-yl]urea 

Relevant articles and documents

ALKYNYL QUINAZOLINE COMPOUNDS

The present disclosure relates to compounds of Formula (I'): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the prevention or treatment of abnormal cell growth in mammals, especially humans.

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND APPLICATION

A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. (I)

New Synthetic Route to Tucatinib

A new and improved synthetic route to tucatinib is described that involves three key intermediates. The first of these, 4-([1,2,4]triazolo[1,5- a ]pyridin-7-yloxy)-3-methylaniline, was prepared on a 100 g scale in 33percent yield over five steps and 99percent purity. Next, N 4 -(4-([1,2,4]triazolo[1,5- a ]pyridin-7-yloxy)-3-methylphenyl)quinazoline-4,6-diamine was isolated in 67percent yield over three steps and >99percent purity. Then, 4,4-dimethyl-2-(methylthio)-4,5-dihydrooxazole trifluoromethanesulfonate was prepared under mild conditions in 67percent yield over two steps. Finally, tucatinib was obtained in 17percent yield over nine steps and in >99percent purity (HPLC). Purification methods used to isolate the product and the intermediates involved in the route are also reported.