875309-83-4 Usage
Description
L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, phenylmethyl ester (monotrifluoroacetate) is a complex chemical compound that combines phenylalanine, leucine, phenylmethyl ester, and monotrifluoroacetate. L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, phenylmethyl ester (monotrifluoroacetate) is notable for its unique structure and potential applications in various fields, including medicine, biochemistry, and material science.
Uses
Used in Pharmaceutical Industry:
L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, phenylmethyl ester (monotrifluoroacetate) is used as an active pharmaceutical ingredient for the development of new drugs. The presence of essential amino acids like phenylalanine and leucine, along with the phenylmethyl ester and monotrifluoroacetate components, may contribute to the compound's therapeutic properties and potential use in treating various medical conditions.
Used in Biochemical Research:
In the field of biochemistry, L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, phenylmethyl ester (monotrifluoroacetate) can be utilized as a research tool to study the interactions between amino acids, organic compounds, and catalysts. This may help scientists better understand the underlying mechanisms of various biological processes and develop new strategies for drug discovery and development.
Used in Material Science:
L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, phenylmethyl ester (monotrifluoroacetate) may also find applications in material science, where it could be used to develop new materials with unique properties. L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, phenylmethyl ester (monotrifluoroacetate)'s structure and components could potentially be harnessed to create innovative materials for various industries, such as electronics, textiles, or construction.
Check Digit Verification of cas no
The CAS Registry Mumber 875309-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,5,3,0 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 875309-83:
(8*8)+(7*7)+(6*5)+(5*3)+(4*0)+(3*9)+(2*8)+(1*3)=204
204 % 10 = 4
So 875309-83-4 is a valid CAS Registry Number.
875309-83-4Relevant articles and documents
Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy to Overcome Cancer Resistance to Carfilzomib and Bortezomib
Lee, Min Jae,Bhattarai, Deepak,Yoo, Jisu,Miller, Zach,Park, Ji Eun,Lee, Sukyeong,Lee, Wooin,Driscoll, James J.,Kim, Kyung Bo
, p. 4444 - 4455 (2019/05/08)
Over the past 15 years, proteasome inhibitors (PIs), namely bortezomib, carfilzomib (Cfz) and ixazomib, have significantly improved the overall survival and quality-of-life for multiple myeloma (MM) patients. However, a significant portion of MM patients do not respond to PI therapies. Drug resistance is present either de novo or acquired after prolonged therapy through mechanisms that remain poorly defined. The lack of a clear understanding of clinical PI resistance has hampered the development of next-generation PI drugs to treat MM patients who no longer respond to currently available therapies. Here, we designed and synthesized novel epoxyketone-based PIs by structural modifications at the P1′ site. We show that a Cfz analog, 9, harboring a hydroxyl substituent at its P1′ position was highly cytotoxic against cancer cell lines displaying de novo or acquired resistance to Cfz. These results suggest that peptide epoxyketones incorporating P1′-targeting moieties may have the potential to bypass resistance mechanisms associated with Cfz and to provide additional clinical options for patients resistant to Cfz.
