89213-87-6 Usage
Description
ANP 1-28, HUMAN is a 28 amino acid peptide derived from the atrial natriuretic peptide (ANP), which is an endogenous peptide generated by proteolysis of prepro-ANP secreted by cardiomyocytes in the heart. It plays a crucial role in regulating the renal and cardiovascular systems by decreasing vasoconstriction, inhibiting renin secretion, and increasing sodium excretion.
Used in Pharmaceutical Industry:
ANP 1-28, HUMAN is used as a therapeutic agent for the treatment of decompensated congestive heart failure. It helps improve hemodynamics and symptoms in patients with acute congestive heart failure (CHF) and has been reported to be well tolerated with no significant adverse effects clinically.
Used in Cardiovascular Research:
ANP 1-28, HUMAN is used as a research tool to study the effects of ANP on the renal and cardiovascular systems, as well as its potential role in the treatment of heart failure and other cardiovascular diseases. It helps researchers understand the mechanisms of action and develop new therapeutic strategies for managing heart failure and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 89213-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,2,1 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 89213-87:
(7*8)+(6*9)+(5*2)+(4*1)+(3*3)+(2*8)+(1*7)=156
156 % 10 = 6
So 89213-87-6 is a valid CAS Registry Number.
InChI:InChI=1/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,
89213-87-6Relevant articles and documents
One-Pot/Sequential Native Chemical Ligation Using Photocaged Crypto-thioester
Aihara, Keisuke,Yamaoka, Kosuke,Naruse, Naoto,Inokuma, Tsubasa,Shigenaga, Akira,Otaka, Akira
, p. 596 - 599 (2016)
A practical and efficient methodology for the chemical synthesis of peptides/proteins using a one-pot/sequential ligation is described. It features the use of photocleavable S-protection on an N-sulfanylethylaniline moiety. Removal of the S-protecting ligated materials under UV irradiation provides a readily usable mixture for subsequent native chemical ligation.
3-Nitro-2-pyridinesulfenates as Efficient Solution- and Solid-Phase Disulfide Bond Forming Agents
Taguchi, Akihiro,Kobayashi, Kiyotaka,Kotani, Akira,Muguruma, Kyohei,Kobayashi, Misaki,Fukumoto, Kentarou,Takayama, Kentaro,Hakamata, Hideki,Hayashi, Yoshio
supporting information, p. 8262 - 8267 (2017/06/23)
In this paper, a new disulfide-forming agent based on the finding that alkoxy 3-nitro-2-pyridinesulfenates (Npys-OR) can oxidize thiol groups is reported. Methyl 3-nitro-2-pyridinesulfenate (Npys-OMe), which is easily prepared from 3-nitro-2-pyridinesulfenyl chloride in a one-step reaction and has a reduction peak potential (Epc) of ?0.541 V versus Ag/AgCl, produces the cyclic nonapeptide oxytocin from its linear form in good yield (92 %) with minimal oligomer formation. Npys-OMe in the solid phase also demonstrated excellent results in oxytocin synthesis. Other disulfide-containing peptides, such as α-human atrial natriuretic peptide and α-conotoxin ImI, were also successfully synthesized. During these syntheses, no side reactions of methionine (Met) and tryptophan (Trp) residues or the S-acetamidomethyl (Acm) protecting group were detected. These results suggested that Npys-OMe or its solid-phase analog provides a new strategy for regioselective disulfide bond formation to assist the synthesis of complex disulfide-rich peptides.
