Rapid determination of HYDROFLUMETHIAZIDE (cas 135-09-1) in dosage forms by time-resolved chemiluminescence

Add time:10/01/2019    Source:infona.pl

. HYDROFLUMETHIAZIDE (cas 135-09-1) was determined from the chemiluminescence produced in its reaction with Ce(IV) in acidic medium containing rhodamine 6G as a sensitizer using flow injection techniques (stopped flow mode). A straightforward automatic method based on measuring the peak height and peak area, which are directly proportional to the hydroflumethiazide concentration, was thus developed. The calibration graphs were linear over the concentration range of 1.0–30 µg mL−1. The limit of detection as determined according to Clayton was 0.97 and 0.91 µg mL−1 for peak height and peak area measurements, respectively. The relative standard deviation for ten samples was less than 3.0% with both types of measurements. The procedure was applied to the determination of hydroflumethiazide in pharmaceutical formulations, yielding excellent recoveries, since the determination is free of interference from common excipients and other drugs which are present in the formulation.

We also recommend Trading Suppliers and Manufacturers of HYDROFLUMETHIAZIDE (cas 135-09-1). Pls Click Website Link as below: cas 135-09-1 suppliers

Prev:Direct vascular actions of Methyclothiazide (cas 135-07-9) in remodeled mesenteric arteries from hypertensive patients
Next:10-Formyl-5,10-dideaza-acyclic-5,6,7,8-TETRAHYDROFOLIC ACID (cas 135-16-0) (10-Formyl-DDACTHF))