- The iodine-mediated highly regioselective synthesis of angular and linear naphthofuroquinones
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Naphthofuroquinones are of great value in medicinal chemistry. In this letter, a facile method for highly regioselective synthesis of both linear and angular naphthofuroquinones has been developed via iodine mediated cyclization of 2-hydroxy-3-substituted
- Liu, Suyou,Long, Lijun,Xie, Duoduo,Liu, Lijun,Ma, Dayou
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- Method for synthesizing coumarone naphthoquinone derivative
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The invention discloses a method for synthesizing a coumarone naphthoquinone derivative. The method comprises the following steps that 2-hydroxyl-3-substituted ethylene-1,4-naphthoquinone is used as raw materials, and the angular coumarone naphthoquinone derivative is synthesized in an organic solvent under the effect of iodine; or the 2-hydroxyl-3-substituted ethylene-1,4-naphthoquinone is used as raw materials, the angular coumarone naphthoquinone derivative is firstly synthesized in an organic solvent under the effect of the iodine, and then, the angular coumarone naphthoquinone derivative is used for synthesizing the straight coumarone naphthoquinone derivative under the acid condition. The method has the advantages that the experiment steps are few; the operation is simple; the selectivity is high; the yield is high; a higher application value is realized.
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Paragraph 0070; 0083; 0084; 0085
(2016/10/08)
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- A New Route to Naphthofuran-4,9-diones from Thio-substituted 1,4-Naphthoquinones
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Reaction of 2-phenylthio- or 2-ethylthio-1,4-naphthoquinones (1) and (2) with lithium enolates or pyridinium ylides was found to give alkylated 1,4-naphthoquionones (3)-(6) in high yields.Alkylated 1,4-naphthoquinones (5) and (6) were then effectively cyclized to 2-substituted naphthofuran-4,9-diones (8) by action of bromine in acetic acid.
- Kang, Wen-Bing,Sekiya, Takashi,Toru, Takeshi,Ueno, Yoshio
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p. 441 - 445
(2007/10/02)
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