292150-20-0Relevant articles and documents
CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE
-
Paragraph 0102-0107, (2017/10/24)
The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as showed by formula I. In detail, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.
A novel immunostimulator, N2-[α-O-Benzyl-N-(acetylmuramyl) -L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen
Yang, Hong-Zhen,Xu, Song,Liao, Xue-Yan,Zhang, Suo-De,Liang, Zheng-Lun,Liu, Bai-He,Bai, Jin-Ye,Jiang, Chao,Ding, Jian,Cheng, Gui-Fang,Liu, Gang
, p. 5112 - 5122 (2007/10/03)
N2-[α-O-Benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl] -N6-trans-(m-nitrocinnamoyl)-L-lysine (muramyl dipeptide C, or MDP-C) has been synthesized as a novel, nonspecific immunomodulator. The present study shows that MDP-C induces