Synthesis p. 950 - 952 (1988)
Update date:2022-09-26
Topics:
Alabaster, Ramon J.
Cottrell, Ian F.
Marley, Hugh
Wright, Stanley H. B.
The preparation of 2,3-dihydrobenzofurans 6 from 2-(2-bromophenoxy)ethyl chlorides 3 by reaction with magnesium in a development of the Parham cyclialkylation reaction is described.A high yielding procedure using phase-transfer catalysis has also been developed for the preparation of the intermediate chloroethyl ethers 3 from bromophenols 2.The 5-hydroxy derivative 15 may be obtained from 2,3-dihydrobenzofuran (6a) by reaction with electrophilic reagents followed by oxidation.
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