Chemical and Pharmaceutical Bulletin p. 372 - 381 (2019)
Update date:2022-08-05
Topics:
Liang, Jie
Tang, Yun-xiang
Tang, Xiang-zheng
Liang, Hua-ju
Gao, Yamin
Fang, Cuiting
Zhang, Tian-yu
Yan, Ming
A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains. The compounds did not show inhibitory activity against normal Gram-positive and Gram-negative bacteria. Moderate cytotoxicities and good metabolic stability were observed for the selected compounds. The results demonstrated meta-amido bromophenols as a new class of antitubercular agents with good potentials.
View Morewebsite:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD
Contact:29-63685658 63685359
Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Wuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Contact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Doi:10.1021/ja00731a033
(1971)Doi:10.1016/S0008-6215(00)82291-0
(1966)Doi:10.1039/b002999h
(2000)Doi:10.1016/S0040-4039(00)01477-5
(2000)Doi:10.1007/BF00909220
(1971)Doi:10.1002/hlca.19800630511
(1980)