Fostriecin sodium

Base Information

• Chemical Name: Fostriecin sodium
• CAS No.: 87860-39-7
• Deprecated CAS: 96612-73-6
• Molecular Formula: C₁₉H₂₆O₉P*Na
• Molecular Weight: 452.374
• UNII: 8TXS63IX8M
• NCI Thesaurus Code: C175067
• Nikkaji Number: J1.595.880D
• Wikidata: Q27271007
• Mol file: 87860-39-7.mol

Synonyms:CI 920;CI-920;fostriecin;PD 110161;PD-110,161

Chemical Property of Fostriecin sodium

Chemical Property:

• Vapor Pressure: 3.93E-25mmHg at 25°C
• Boiling Point: 737.9°C at 760 mmHg
• Flash Point: 400.1°C
• PSA: 166.39000
• LogP: 1.49330
• Storage Temp.: −20°C
• Solubility.: Soluble in H2O
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 11
• Exact Mass: 452.12121368
• Heavy Atom Count: 30
• Complexity: 732

Purity/Quality:

98%,99%, ^*data from raw suppliers

FST ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
• Isomeric SMILES: C[C@@](/C=C/[C@H]1CC=CC(=O)O1)([C@@H](C[C@H](/C=C\C=C/C=C/CO)O)OP(=O)(O)[O-])O.[Na+]
• Description: Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.
• Uses: Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor. Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS). It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.