4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE
• CAS No.: 4465-65-0
• Molecular Formula: C22H23N2O7+
• Molecular Weight: 462.88
• Hs Code.: 29413000
• Mol file: 4465-65-0.mol

Synonyms:4-Epianhydrotetracycline HCl;(4R,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide,hydrochloride;

Chemical Property of 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 3.66E-16mmHg at 25°C
• Melting Point: 220oC
• Boiling Point: 618.6°C at 760 mmHg
• Flash Point: 327.9°C
• PSA: 161.39000
• LogP: 1.95810
• Storage Temp.: -20?C Freezer

Purity/Quality:

98%Min ^*data from raw suppliers

4-Epianhydrotetracycline hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 63-36-22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An antibiotic derived from Tetracycline. Studies have shown that this derivative can have a 250-fold higher toxicity depending on the system under study. Epianhydrotetracycline is a secondary degradation product formed by epimerisation of tetracycline and dehydration at the C6 position to aromatise the B ring. Epianhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, epianhdrotetracycline is considered biologically active and is thought responsible for aspects tetracycline toxicity.

Technology Process of 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE

There total 2 articles about 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-epi-anhydrotetracycline hydrochloride (4465-65-0)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01568a050

Reference yield:

anhydrotetracycline hydrochloride (13803-65-1) → 4-epi-anhydrotetracycline hydrochloride (4465-65-0)

Guidance literature:

at 25 ℃; Gleichgewicht;

DOI:10.1021/ja01568a050

Reference yield:

4-epi-anhydrotetracycline hydrochloride (4465-65-0) → anhydrotetracycline hydrochloride (13803-65-1)

Guidance literature:

at 25 ℃; Gleichgewicht;

DOI:10.1021/ja01568a050

upstream raw materials:

anhydrotetracycline hydrochloride

Downstream raw materials:

anhydrotetracycline hydrochloride