Concanamycin A, >=70% (HPLC)

Base Information

• Chemical Name: Concanamycin A, >=70% (HPLC)
• CAS No.: 80890-47-7
• Molecular Formula: C46H75NO14
• Molecular Weight: 866.086
• Hs Code.: 2941900000
• European Community (EC) Number: 620-709-4
• Metabolomics Workbench ID: 66288
• Wikidata: Q105104026
• Mol file: 80890-47-7.mol

Synonyms:concanamycin A;folimycin;TAN 1323 B;TAN-1323 B

Chemical Property of Concanamycin A, >=70% (HPLC)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 179-180℃ (dichloromethane ethanol )
• Boiling Point: 966.4°Cat760mmHg
• PKA: 12.46±0.70(Predicted)
• Flash Point: 538.3°C
• PSA: 225.92000
• Density: 1.2g/cm³
• LogP: 5.68420
• Storage Temp.: −20°C
• Solubility.: Soluble in DMSO
• XLogP3: 6
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 12
• Exact Mass: 865.51875607
• Heavy Atom Count: 61
• Complexity: 1580

Purity/Quality:

98%,99%, ^*data from raw suppliers

Concanamycin A ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 26/27/28-36
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
• Isomeric SMILES: CCC1C(C(C/C(=C/C=C/C(C(OC(=O)/C(=C/C(=C/C(C1O)C)/C)/OC)C(C)C(C(C)[C@@]2(C[C@H]([C@@H](C(O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
• Description: Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
• Uses: Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins. Concanamycin A has been used: as a lysosomal inhibitor in young and old fibroblasts as a vacuolar-type H+-ATPase inhibitor in presynaptic vesiclesas a lysosomal acidification blocker in HepG2 hepatocytes cells