Methyl 2-(2-hydroxyphenyl)acetate

Base Information

• Chemical Name: Methyl 2-(2-hydroxyphenyl)acetate
• CAS No.: 22446-37-3
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2942000000
• European Community (EC) Number: 245-004-5
• DSSTox Substance ID: DTXSID30176989
• Nikkaji Number: J127.889D
• Wikidata: Q83047314
• ChEMBL ID: CHEMBL450221
• Mol file: 22446-37-3.mol

Synonyms:Methyl 2-(2-hydroxyphenyl)acetate;22446-37-3;(2-Hydroxy-phenyl)-acetic acid methyl ester;Methyl (2-hydroxyphenyl)acetate;Benzeneacetic acid, 2-hydroxy-, methyl ester;MFCD00090077;(2-hydroxyphenyl)acetic acid methyl ester;Acetic acid, (o-hydroxyphenyl)-, methyl ester;EINECS 245-004-5;methyl(2-hydroxyphenyl)acetate;Methyl 2-hydroxyphenyl acetate;Methyl2-(2-hydroxyphenyl)acetate;Methyl o-hydroxyphenylacetate;methyl 2-hydroxyphenylacetate;SCHEMBL392976;CHEMBL450221;Methyl 2-hydroxy-benzeneacetate;DTXSID30176989;CHEBI:180585;methyl-2-(2-hydroxyphenyl)acetate;BCP17205;AKOS006240720;2-Hydroxyphenylacetic acid methyl ester;CS-W019150;o-Hydroxyphenylacetic acid, methyl ester;2-Hydroxyphenylacetic acid, methyl ester;2-Hydroxy-benzeneacetic acid methyl ester;AS-12074;SY032006;FT-0693526;EN300-83058;A878532;J-509687;Z1010319062

Chemical Property of Methyl 2-(2-hydroxyphenyl)acetate

Chemical Property:

• Vapor Pressure: 0.00692mmHg at 25°C
• Melting Point: 122-124℃
• Refractive Index: 1.539
• Boiling Point: 261.9 °C at 760 mmHg
• PKA: 9.55±0.30(Predicted)
• Flash Point: 110 °C
• PSA: 46.53000
• Density: 1.181g/cm³
• LogP: 1.10770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, Methanol (Slightly)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 156

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-(2-Hydroxyphenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CC1=CC=CC=C1O
• Uses: Methyl 2-(2-Hydroxyphenyl)acetate is used as a reactant in the preparation of caffeic acid phenylethyl esters as ?antiproliferative agents.

Technology Process of Methyl 2-(2-hydroxyphenyl)acetate

There total 25 articles about Methyl 2-(2-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 2-Hydroxyphenylacetic acid (614-75-5) → methyl (2-hydroxyphenyl)acetate (22446-37-3)

Guidance literature:

With sulfuric acid; for 3h; Heating; Inert atmosphere; Reflux;

DOI:10.1039/c3ob41065j

Reference yield: 99.0%

methanol (67-56-1) + benzofuran-2(3H)-one (553-86-6) → methyl (2-hydroxyphenyl)acetate (22446-37-3)

Guidance literature:

hydrogenchloride; at 50 ℃; for 0.5h;

Reference yield: 95.0%

methanol (67-56-1) + 2'-chloro-benzeneacetic acid (2444-36-2) → methyl (2-hydroxyphenyl)acetate (22446-37-3)

Guidance literature:

2'-chloro-benzeneacetic acid; With copper(l) chloride; sodium hydroxide; In water; at 250 ℃; for 8h; Autoclave;

methanol; With sulfuric acid; In dichloromethane; Temperature; Reflux;

upstream raw materials:

diazomethane

2-Hydroxyphenylacetic acid

methanol

methyl 2-phenoxyacetate

Downstream raw materials:

α-Phenyl-(o-carbomethoxymethyl)-phenoxy-acetat

[2-(4,6-dimethoxy-pyrimidin-2-yloxy)-phenyl]-acetic acid methyl ester

methyl 2-(2-methoxyphenyl)acetate

2-benzyloxyphenylacetic acid methyl ester

Refernces

• 1、 Zhang, Xiaojie,Beaudry, Christopher M.. "Regioselective Synthesis of Benzofuranones and Benzofurans". . p. 6931 - 6936. Retrieved 2021.
• 2、 Dong, Shanliang,Hu, Wenhao,Huang, Jingjing,Qiu, Lihua,Sha, Hongkai,Xu, Xinfang. "Copper-catalyzed formal [1 + 2 + 2]-annulation of alkyne-tethered diazoacetates and pyridines: Access to polycyclic indolizines". . p. 1926 - 1932. Retrieved 2020.
• 3、 -. "Preparation method of carboxylic ester compound". Paragraph 0051-0052. . Retrieved 2021/03/30.
• 4、 -. "New compound used as rearranged during transfection kinase inhibitor". Paragraph 0176; 0177. . Retrieved 2021/03/05.