4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97

Base Information

• Chemical Name: 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97
• CAS No.: 14206-58-7
• Molecular Formula: C22H24 N2 O9
• Molecular Weight: 461.4414
• Hs Code.: 29413020
• Mol file: 14206-58-7.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,[4R-(4a,4ab,5b,5ab,6a,12ab)]-; Quatrimycin, hydroxy- (6CI); 4-epi-Oxytetracycline

Chemical Property of 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97

Chemical Property:

• Vapor Pressure: 3.09E-22mmHg at 25°C
• Melting Point: 168oC
• Boiling Point: 727.8°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 394°C
• PSA: 202.84000
• Density: g/cm³
• LogP: -0.25050
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

95-99% ^*data from raw suppliers

4-epi-Oxytetracycline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Epioxytetracycline is a degradation product of the antibiotic oxytetracycline . It has been found in swine manure compost and wastewater and is considered a pollutant.
• Uses: A metabolite of Oxytetracycline Epioxytetracycline is a degradation product of oxytetracycline formed by the epimerisation of the dimethylamino group at C4 in solution at neutral to acidic pH. The epimerisation is associated with a loss of antibiotic activity. Epioxytetracycline is an important standard for monitoring oxytetracycline stability.

Technology Process of 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97

There total 3 articles about 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Oxytetracycline (79-57-2) → 4-epi-oxytetracycline (14206-58-7)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01568a050

Reference yield:

→ dl-Terramycin (79-57-2,14206-58-7,22042-27-9,35259-39-3,65309-81-1)

Guidance literature:

Aminohydrochlorid 47, Diisopropylethylamin, Dimethylsulfat;

DOI:10.1021/ja00497a035

Reference yield:

→ (4S,4aR,5S,6S,12aS)-4-Dimethylamino-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide (79-57-2,14206-58-7,22042-27-9,35259-39-3,65309-81-1,6153-64-6)

Guidance literature:

Isolierung durch Ionenaustauschchromatographie;

upstream raw materials:

Oxytetracycline

Refernces

• 1、 Muxfeldt,Haas,Hardtmann,et al.. "Tetracyclines. IX. Total synthesis of dl-terramycin". . p. 689 - 701. Retrieved 2007/10/04.