Technology Process of Onitin
There total 9 articles about Onitin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
at 0 - 20 ℃;
for 4.5h;
chemoselective reaction;
DOI:10.1021/acs.jnatprod.8b00335
- Guidance literature:
-
With
hydrogen bromide; acetic acid;
at 80 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: bromine / chloroform / 0 °C
2: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 44 h / 140 - 145 °C / Schlenk technique; Inert atmosphere
3: p-benzoquinone; dichloro bis(acetonitrile) palladium(II); water / tert-butyl alcohol / 2 h / 85 °C
4: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
5: sodium tris(acetoxy)borohydride / dichloromethane / 4.5 h / 0 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; dichloro bis(acetonitrile) palladium(II); water; bromine; boron tribromide; sodium tris(acetoxy)borohydride; caesium carbonate; p-benzoquinone;
In
dichloromethane; chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;
2: |Suzuki-Miyaura Coupling / 3: |Wacker Oxidation;
DOI:10.1021/acs.jnatprod.8b00335