N-ACETYLOXINDOLE 97

Base Information

• Chemical Name: N-ACETYLOXINDOLE 97
• CAS No.: 21905-78-2
• Molecular Formula: C10H9 N O2
• Molecular Weight: 175.187
• Mol file: 21905-78-2.mol

Synonyms:2-Indolinone,1-acetyl- (7CI,8CI); Oxindole, 1-acetyl- (6CI);1-Acetyl-1,2-dihydro-2-oxo-3H-indole; 1-Acetyl-1,3-dihydro-indol-2-one;1-Acetyl-2-indolinone; 1-Acetyl-2-oxoindole; 1-Acetyloxindole; NSC 286428

Chemical Property of N-ACETYLOXINDOLE 97

Chemical Property:

• Vapor Pressure: 1.33E-06mmHg at 25°C
• Melting Point: 127-131 °C(lit.)
• Boiling Point: 399.8°Cat760mmHg
• PKA: -0.58±0.20(Predicted)
• Flash Point: 203.5°C
• PSA: 37.38000
• Density: 1.275g/cm³
• LogP: 1.18720
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Acetyloxindole ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Acetyloxindole is used in the preparation of a potent and bioavailable selective P2Y1 antagonist in the area of antithrombotics. A potential inhibitor of salicylate synthase in mycobacterium tuberculosis.

Technology Process of N-ACETYLOXINDOLE 97

There total 9 articles about N-ACETYLOXINDOLE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-oxoindole (59-48-3) + acetic anhydride (108-24-7) → N-acetyloxindole (21905-78-2)

Guidance literature:

for 3h; Reflux;

DOI:10.1002/cmdc.201000275

Reference yield: 96.0%

→ N-acetyloxindole (21905-78-2)

Guidance literature:

Reference yield: 91.0%

5-diazo-2,2-dimethyl-1,3-dioxane-4,6-dion (7270-63-5) + Acetanilid (103-84-4) → N-acetyloxindole (21905-78-2)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; silver(I) triflimide; In 1,4-dioxane; at 70 ℃; for 10h; Reagent/catalyst; Temperature;

DOI:10.1039/C6CC08788D

upstream raw materials:

2-oxoindole

acetic anhydride

2-(2-acetamidophenyl)acetic acid

N-acetylindole

Downstream raw materials:

2-(2-acetamidophenyl)acetic acid

Refernces

• 1、 Edupuganti, Ramakrishna,Taliaferro, Juliana M.,Wang, Qiantao,Xie, Xuemei,Cho, Eun Jeong,Vidhu, Fnu,Ren, Pengyu,Anslyn, Eric V.,Bartholomeusz, Chandra,Dalby, Kevin N.. "Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth". . p. 2609 - 2616. Retrieved 2017/04/06.
• 2、 -. "COMPOUND; TAUTOMER AND GEOMETRIC ISOMER THEREOF; SALT OF SAID COMPOUND, TAUTOMER, OR GEOMETRIC ISOMER; METHOD FOR MANUFACTURING SAID COMPOUND, TAUTOMER, ISOMER, OR SALT; ANTIMICROBIAL AGENT; AND ANTI-INFECTIVE DRUG". Paragraph 0167-0168; 0169. . Retrieved 2015/09/23.