Imipenem and cilastatin

Base Information

• Chemical Name: Imipenem and cilastatin
• CAS No.: 92309-29-0
• Molecular Formula: C28H43N5O9S2
• Molecular Weight: 697.8
• Hs Code.: 3003209000
• ChEMBL ID: CHEMBL1628401
• Mol file: 92309-29-0.mol

Synonyms:Cilastatin, Imipenem;cilastatin, imipenem drug combination;imipenem - cilastatin;Imipenem - Cilastatin Sodium;Imipenem Cilastatin;Imipenem Cilastatin Sodium;Imipenem Cilastatin, Sodium Salt;imipenem-cilastatin;Imipenem-Cilastatin Sodium;imipenem-cilastatin, sodium salt;MK 0787 MK 0791 mixture;MK 0787-MK 0791 mixture;MK 787 MK 791 mixture;MK 787-MK 791 mixture;Primaxin;Thienam;Tienam 500;Zienam

Chemical Property of Imipenem and cilastatin

Chemical Property:

• Vapor Pressure: 7.13E-19mmHg at 25°C
• Boiling Point: 990.4 °C at 760 mmHg
• Flash Point: 552.8 °C
• PSA: 308.60000
• LogP: 1.37730
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 17
• Exact Mass: 657.25022031
• Heavy Atom Count: 44
• Complexity: 1010

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)O)C
• Isomeric SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.CC1(C[C@@H]1C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)/C(=O)O)C
• Recent ClinicalTrials: A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
• Recent EU Clinical Trials: Finding the Optimal Regimen for Mycobacterium abscessus Treatment
• Drug interactions: Potentially hazardous interactions with other drugs Antiepileptics: reduced valproate concentration - avoid. Antivirals: convulsions reported with concomitant administration of ganciclovir and valganciclovir. Ciclosporin: variable reports of increase / no change in ciclosporin levels, and of neurotoxicity.