Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-
There total 5 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium 2-ethylhexanoic acid;
In
acetone;
at 5 ℃;
for 1h;
Temperature;
- Guidance literature:
-
C15H16N7O5S3(1-)*C9H13N*Na(1+);
With
sulfuric acid;
In
water; ethyl acetate;
at 0 - 10 ℃;
pH=1 - 3;
With
sodium hydrogencarbonate;
In
water;
at 0 - 5 ℃;
pH=4 - 6;
Reagent/catalyst;
- Guidance literature:
-
C15H16N7O5S3(1-)*Li(1+)*C12H23N;
With
phosphoric acid;
In
water; ethyl acetate;
at 0 - 10 ℃;
pH=1 - 3;
With
sodium carbonate;
In
water;
at 0 - 5 ℃;
pH=4 - 6;