HESPERETIN

Base Information

• Chemical Name: HESPERETIN
• CAS No.: 41001-90-5
• Molecular Formula: C16H14O6
• Molecular Weight: 302.27900
• Hs Code.: 2932999099
• Mol file: 41001-90-5.mol

Synonyms:

Chemical Property of HESPERETIN

Chemical Property:

• Vapor Pressure: 2.45E-14mmHg at 25°C
• PSA: 96.22000
• LogP: 2.51850
• Storage Temp.: 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

Safty Information:

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HESPERETIN

There total 38 articles about HESPERETIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

7-hydroxy-4-methyl-chromen-2-one (90-33-5,79566-13-5) + hesperidin (520-26-3) → 4-methylumbelliferyl-rutinoside (1356391-89-3) + hesperetin (520-33-2,41001-90-5,69097-99-0)

Guidance literature:

With water; In dimethyl sulfoxide; at 30 ℃; for 1h; pH=5; aq. buffer; Enzymatic reaction;

DOI:10.1016/j.carres.2011.11.008

Reference yield: 3.5%

hesperidin (520-26-3) → hesperetin (520-33-2,41001-90-5,69097-99-0) + 3′,5,7,8-tetrahydroxy-4′-methoxyflavanone

Guidance literature:

With Aspergillus saitoi; In water; dimethyl sulfoxide; at 30 ℃; pH=5.0;

DOI:10.1271/bbb.67.1443

Reference yield:

hesperetin 7‐O‐β‐D‐glucopyranoside → β-D-glucose (492-61-5) + hesperetin (520-33-2,41001-90-5,69097-99-0)

Guidance literature:

With water; Enzymatic reaction;

DOI:10.1016/j.carres.2011.11.008

upstream raw materials:

hesperidin

4^G-α-D-glucopyranosyl hesperidin

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

methanol

Downstream raw materials:

5-hydroxy-3′4′7-trimethoxy flavanone

(S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one

(-)-hesperetin oxime

5-hydroxy-6,3',4'-trimethoxyflavanone

Refernces

• 1、 Dong, Hao,Yang, Xiaocui,He, Jiapeng,Cai, Sheng,Xiao, Kaijun,Zhu, Liang. "Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(II) and its inhibition kinetics on xanthine oxidase". . p. 53385 - 53395. Retrieved 2017.
• 2、 Di Donna, Leonardo,De Luca, Giuseppina,Mazzotti, Fabio,Napoli, Anna,Salerno, Raffaele,Taverna, Domenico,Sindona, Giovanni. "Statin-like principles of bergamot fruit (Citrus bergamia): Isolation of 3-hydroxymethylglutaryl flavonoid glycosides". . p. 1352 - 1354. Retrieved 2009.
• 3、 Lu, Shengmin,Xing, Jianrong,Zheng, Meiyu. "Enhanced antioxidant, anti-inflammatory and α-glucosidase inhibitory activities of citrus hesperidin by acid-catalyzed hydrolysis". . . Retrieved 2021.
• 4、 Wang, Qian-Qian,Shi, Jing-Bo,Chen, Chen,Huang, Cheng,Tang, Wen-Jian,Li, Jun. "Hesperetin derivatives: Synthesis and anti-inflammatory activity". . p. 1460 - 1465. Retrieved 2016.
• 5、 Miyake, Yoshiaki,Minato, Kenichiro,Fukumoto, Syuichi,Yamamoto, Kanefumi,Oya-Ito, Tomoko,Kawakishi, Syunro,Osawa, Toshihiko. "New potent antioxidative hydroxyflavanones produced with Aspergillus saitoi from flavanone glycoside in citrus fruit.". . p. 1443 - 1450. Retrieved 2003.
• 6、 Bornscheuer, Uwe T.,Brückner, Stephan I.,Gei?ler, Torsten,Gross, Egon,Hartmann, Beate,Ley, Jakob P.,Meinert, Hannes,R?ttger, Carsten,Schuiten, Eva,Yi, Dong,Zirpel, Bastian. "Discovery of Novel Bacterial Chalcone Isomerases by a Sequence-Structure-Function-Evolution Strategy for Enzymatic Synthesis of (S)-Flavanones". supporting information. p. 16874 - 16879. Retrieved 2021/07/06.