6-Deoxy-4-epioxytetracycline

Base Information

• Chemical Name: 6-Deoxy-4-epioxytetracycline
• CAS No.: 6543-77-7
• Molecular Formula: C22H24 N2 O8
• Molecular Weight: 444.43
• Mol file: 6543-77-7.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,4-epimer (8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4R-(4a,4ab,5b,5ab,6b,12ab)]-; 4-Epidoxycycline; 4-Epioxytetracycline, 6-deoxy-

Chemical Property of 6-Deoxy-4-epioxytetracycline

Chemical Property:

• Vapor Pressure: 1.03E-19mmHg at 25°C
• Melting Point: >176?C (dec.)
• Boiling Point: 685.2°C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 368.2°C
• PSA: 181.62000
• Density: 1.63g/cm³
• LogP: 0.35270
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

4-EpiDoxycycline(>70%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An alternative to doxycycline to control gene expression. An alternative to doxycycline to control gene expression

Technology Process of 6-Deoxy-4-epioxytetracycline

There total 3 articles about 6-Deoxy-4-epioxytetracycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-epi-6-Desoxy-5-hydroxy-tetracyclin (564-25-0,3219-99-6,6543-77-7,22775-54-8,60080-38-8,97583-08-9,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

6-Desoxy-5-hydroxy-tetracyclin, wss.-methanol. NaH2PO4, N2-Atm., 24h, 25grad; als Gleichgew.-Gemisch;

DOI:10.1021/ja01498a037

Reference yield:

→ 6-Epi-6-desoxy-5-oxytetracyclin (564-25-0,3219-99-6,6543-77-7,22775-54-8,60080-38-8,97583-08-9,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

6-Desoxy-6-desmethyl-6-methylen-5-oxytetracyclin, 1.) H2, Rh/C, 2.) Trennung ueber Sulfosalicylsaeuresalze;

Reference yield:

doxycycline (564-25-0,10597-92-9,7164-70-7,7264-10-0) → 4-epidoxycycline (6543-77-7,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

With acetic acid; for 24h; Ambient temperature;

upstream raw materials:

doxycycline

Refernces