4-Amino-2-hydroxybenzyl alcohol

Base Information

• Chemical Name: 4-Amino-2-hydroxybenzyl alcohol
• CAS No.: 40463-78-3
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.154
• Mol file: 40463-78-3.mol

Synonyms:4-Amino-2-hydroxybenzyl alcohol

Chemical Property of 4-Amino-2-hydroxybenzyl alcohol

Chemical Property:

• Boiling Point: 311.6±12.0 °C(Predicted)
• PKA: 9.98±0.10(Predicted)
• PSA: 66.48000
• Density: 1.338±0.06 g/cm3(Predicted)
• LogP: 1.04790
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4-amino-2-hydroxybenzylalcohol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-saligenin is a derivative of Saligenin (H809700), a phenolic component of a part of a salix bark extract which maintains a minor anti-depressant effect. Phenolic analog with potential for anti-melanomic effect.

Technology Process of 4-Amino-2-hydroxybenzyl alcohol

There total 4 articles about 4-Amino-2-hydroxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(hydroxymethyl)-5-nitrophenol (57356-40-8) → 4-Hydroxymethyl-3-hydroxyanilin (40463-78-3)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation;

Reference yield:

acetic acid 2-bromomethyl-5-nitrophenyl ester (98590-42-2) → 4-Hydroxymethyl-3-hydroxyanilin (40463-78-3)

Guidance literature:

Multi-step reaction with 3 steps

2: aq.-ethanolic HCl

3: palladium/charcoal; ethanol / Hydrogenation

With hydrogenchloride; palladium on activated charcoal; ethanol;

Reference yield:

2-acetoxy-1-acetoxymethyl-4-nitro-benzene (353276-02-5) → 4-Hydroxymethyl-3-hydroxyanilin (40463-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic HCl

2: palladium/charcoal; ethanol / Hydrogenation

With hydrogenchloride; palladium on activated charcoal; ethanol;

upstream raw materials:

2-(hydroxymethyl)-5-nitrophenol

acetic acid 2-bromomethyl-5-nitrophenyl ester

2-acetoxy-1-acetoxymethyl-4-nitro-benzene

Refernces