methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate

Base Information

• Chemical Name: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate
• CAS No.: 215934-32-0
• Molecular Formula: C₂₂H₁₇N₃O₅
• Molecular Weight: 403.394
• Mol file: 215934-32-0.mol

Synonyms:methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate;Bankit;Benzeneacetic acid, 2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)-, methyl ester, (E)-;Einecs annex I index 607-256-00-x;Hsdb 7017

Chemical Property of methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate

Chemical Property:

• Vapor Pressure: 1.67E-13mmHg at 25°C
• Melting Point: 116oC
• Boiling Point: 581.3°C at 760 mmHg
• Flash Point: 305.3°C
• PSA: 103.56000
• Density: 1.34g/cm³
• LogP: 4.09318
• Water Solubility.: 6g/L at 20℃

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Hazard Codes: T:Toxic;;
• Statements: R23:; R50/53:
• Safety Statements: S22:; S45:; S60:; S61:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate

There total 51 articles about methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate (131860-97-4) + salicylonitrile (611-20-1) → azoxystrobin (215934-32-0,131860-33-8,143130-94-3)

Guidance literature:

With potassium carbonate; quinuclidine hydrochloride; In 4-methyl-2-pentanone; at 60 - 80 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 100.0%

(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate (131860-97-4) → azoxystrobin (215934-32-0,131860-33-8,143130-94-3)

Guidance literature:

salicylonitrile; With potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 60 ℃; for 0.166667h;

(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate; In N,N-dimethyl-formamide; at 60 - 84 ℃; for 0.333333h; Product distribution / selectivity;

Reference yield: 98.0%

salicylonitrile (611-20-1) → azoxystrobin (215934-32-0,131860-33-8,143130-94-3)

Guidance literature:

(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.0833333h;

salicylonitrile; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 60 - 89 ℃; for 0.166667h; Product distribution / selectivity;

upstream raw materials:

(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate

salicylonitrile

1-methyl-pyrrolidin-2-one

ethylene glycol

Downstream raw materials:

methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate

2-(6-hydroxypyrimidin-4-yloxy)benzonitrile

(E)-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylic acid

Refernces

• 1、 -. "Method for improving conversion rate of azoxystrobin". Paragraph 0066-0069. . Retrieved 2021/03/31.
• 2、 -. "PREPARATION METHOD FOR AZOXYSTROBIN AND INTERMEDIATE THEREOF". . . Retrieved 2021/01/25.