N-Demethyl Rifampin

Base Information

• Chemical Name: N-Demethyl Rifampin
• CAS No.: 13292-45-0
• Molecular Formula: C₄₂H₅₆N₄O₁₂
• Molecular Weight: 808.926
• Mol file: 13292-45-0.mol

Synonyms:2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione,5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-(N-1-piperazinylformimidoyl)-,21-acetate (7CI,8CI);2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.;3-Piperazinoiminomethyl rifamycin SV; 4-N-Demethylrifampicin; AF/AP;Demethylrifampicin; N-Demethylrifampicin; N-Demethylrifampin; NSC 143416;Rifampicin AF/AP

Chemical Property of N-Demethyl Rifampin

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 4.81±0.70(Predicted)
• Flash Point: °C
• PSA: 228.94000
• Density: 1.35g/cm³
• LogP: 4.39790
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-Demethyl rifampin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Demethyl Rifampicin is a metabolite of Rifampicin (R508000). N-Demethyl Rifampin is a metabolite of Rifampicin (R508000).

Technology Process of N-Demethyl Rifampin

There total 2 articles about N-Demethyl Rifampin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazin-1-yl-amine (30651-60-6) + 3-formylrifamycin SV (13292-22-3) → C42H56N4O12 (13292-45-0)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; Molecular sieve;

DOI:10.1021/jm901858n

Reference yield:

→ 3-(piperidinyliminomethyl)rifamycin SV (13292-45-0)

Guidance literature:

RCHO, NH2-Verb.;

upstream raw materials:

piperazin-1-yl-amine

3-formylrifamycin SV

Refernces