CARBENICILLIN INDANYL SODIUM (300 MG)

Base Information

• Chemical Name: CARBENICILLIN INDANYL SODIUM (300 MG)
• CAS No.: 26605-69-6
• Molecular Formula: C26H26 N2 O6 S . Na
• Molecular Weight: 0
• Hs Code.: 2941106000
• Mol file: 26605-69-6.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-(2a,5a,6b)]-; Malonamic acid,N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl-,1-(5-indanyl) ester, monosodium salt (8CI); 5-Indanol, 6-ester with6-(2-carboxy-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid monosodium salt (8CI); 5-Indanol,N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenylmalonamatemonosodium salt (8CI); CP 15464-2; Carbenicillin indanyl sodium; Carindacillinsodium; Carindapen; GU-Pen; Geocillin; Indanyl carbenicillin sodium salt;Monosodium indanyl carbenicillin; Sodium 5-indanylcarbenicillin; Sodiumindanylcarbenicillin

Chemical Property of CARBENICILLIN INDANYL SODIUM (300 MG)

Chemical Property:

• Vapor Pressure: 6.62E-28mmHg at 25°C
• Melting Point: 207-213°
• Boiling Point: 812.5°Cat760mmHg
• Flash Point: 445.2°C
• PSA: 141.14000
• Density: g/cm³
• LogP: 1.49030
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Water (Slightly, Heated, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

SodiumIndanylcarbinicillin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic. Carbenicillin indanyl sodium has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.
• Therapeutic Function: Antibacterial
• Clinical Use: Efforts to obtain orally active forms of carbenicillin led to theeventual release of the 5-indanyl ester carbenicillin indanyl,6-[2-phenyl-2-(5-indanyloxycarbonyl)acetamido]penicillanicacid (Geocillin), in 1972. Approximately 40% of theusual oral dose of indanyl carbenicillin is absorbed. After absorption,the ester is hydrolyzed rapidly by plasma and tissueesterases to yield carbenicillin. Thus, although the highlylipophilic and highly protein-bound ester has in vitro activitycomparable with that of carbenicillin, its activity in vivo isdue to carbenicillin. Indanyl carbenicillin thus provides anorally active alternative for the treatment of carbenicillinsensitivesystemic and urinary tract infections caused byPseudomonas spp., indole-positive Proteus spp., and selectedspecies of Gram-negative bacilli.Clinical trials with indanyl carbenicillin revealed a relativelyhigh frequency of GI symptoms (nausea, occasionalvomiting, and diarrhea). It seems doubtful that the highdoses required for the treatment of serious systemic infectionscould be tolerated by most patients. Indanyl carbenicillinoccurs as the sodium salt, an off-white, bitter powderthat is freely soluble in water. It is stable in acid. It should beprotected from moisture to prevent hydrolysis of the ester.