Cefoselis sulfate

Base Information

• Chemical Name: Cefoselis sulfate
• CAS No.: 122841-12-7
• Molecular Formula: C19H24N8O10S3
• Molecular Weight: 620.64
• UNII: 6EY42207VS
• Mol file: 122841-12-7.mol

Synonyms:cefoselis;FK 037;FK-037;FK037

Chemical Property of Cefoselis sulfate

Chemical Property:

• Boiling Point: 965.8 °C at 760 mmHg
• Flash Point: 537.9 °C
• PSA: 337.67000
• LogP: 0.02710
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 9
• Exact Mass: 620.07775251
• Heavy Atom Count: 40
• Complexity: 1100

Purity/Quality:

99% ^*data from raw suppliers

CefoselissulfateA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O
• Isomeric SMILES: CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O
• Description: Cefoselis is a new fourth-generation cephalosporin and was launched in Japan as a parenteral antibiotic for a variety of infections including Staphylococcus aureus (particularly the methicillin-resistant MRSA) and Pseudornonas aeruginosa. It can be prepared in 3 related ways, all using 2- pyrazolomethyl-3-cephem-4-carboxylic as the key intermediate. In preclinical studies, Cefolesis had better MIC50s than Ceftazidime against Streptococcus pneurnoniae or Staphflococcus aureus (methicillin-sensitive MSSA or resistant MRSA) and showed significant antibacterial activity against Citrobacter and Enterobacter. Cefolesis is well tolerated in clinical studies, being eliminated mainly via glomerular filtration in humans.
• Uses: antibiotic