Proflavine hydrochloride

Base Information

• Chemical Name: Proflavine hydrochloride
• CAS No.: 952-23-8
• Molecular Formula: C13H11 N3 . Cl H
• Molecular Weight: 245.711
• Hs Code.: 2933990090
• European Community (EC) Number: 213-459-9,231-239-0
• NSC Number: 605756
• UNII: 51AA3SI0JM
• DSSTox Substance ID: DTXSID8021191
• Wikidata: Q27144855
• ChEMBL ID: CHEMBL606782
• Mol file: 952-23-8.mol

Synonyms:952-23-8;acridine-3,6-diamine hydrochloride;Proflavine hydrochloride;3,6-Diaminoacridine hydrochloride;Proflavine monohydrochloride;Proflavin hydrochloride;Proflavine HCl;Proflavine.HCl hemihydrate;7459-75-8;3,6-ACRIDINEDIAMINE, MONOHYDROCHLORIDE;3,6-DIAMINOACRIDINE HCL;1,7-Diaminoacridine hydrochloride;3,6-Acridinediamine, hydrochloride;acridine-3,6-diamine;hydrochloride;EINECS 231-239-0;NSC605756;3,6-Diaminoacridine monohydrochloride;Acridine, 3,6-diamino-, hydrochloride;CCRIS 532;3,6-diaminoacridinium chloride;DTXSID8021191;CHEBI:74718;3,6-Acridinediamine xhydrochloride;NCI-C04137;EINECS 213-459-9;Acridine, 3,6-diamino-, monohydrochloride;3,6-Diaminoacridine hydrochloride hemihydrate;2,8-Diaminoacridinium chloride monohydrochloride;UNII-51AA3SI0JM;51AA3SI0JM;diacridine-3,6-diamine dihydrochloride hydrate;proflavine.HCl;3,6-diaminoacridine.HCl;C13H11N3.xClH;proflavine monohy drochloride;C13H11N3.ClH;SCHEMBL664629;CHEMBL606782;DTXCID401191;3,6-Acridinediaminexhydrochloride;C13-H11-N3.x-Cl-H;3.6-Diaminoacridine hydrochloride;proflavine hydrochloride hemihydrate;Tox21_200513;3,6-acridinediamine monohydrochloride;CCG-35221;MFCD00066867;AKOS015894696;LS-1998;NSC-605756;NCGC00258067-01;CAS-952-23-8;CS-0156837;FT-0699261;D84168;A859121;3,6-Diaminoacridine hydrochloride, Dye content 95 %;Q27144855

Chemical Property of Proflavine hydrochloride

Chemical Property:

• Vapor Pressure: 2.14E-10mmHg at 25°C
• Melting Point: 270°C (dec.) (lit.)
• Boiling Point: 506.9°Cat760mmHg
• Flash Point: 292.9°C
• PSA: 64.93000
• Density: 1.346g/cm³
• LogP: 4.51680
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 245.0719751
• Heavy Atom Count: 17
• Complexity: 232

Purity/Quality:

98%,99%, ^*data from raw suppliers

Acridine-3,6-diaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Dyes -> Acridine Dyes
• Canonical SMILES: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.Cl
• Uses: Acridine-3,6-diamine hydrochloride, canbe used for studying cation transfer at the liquid–liquid interface.

Technology Process of Proflavine hydrochloride

There total 2 articles about Proflavine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ D-Galactose (59-23-4) + proflavine hydrochloride (952-23-8)

Guidance literature:

Reference yield:

acridine orange (248928-58-7) → N-de-mono-methyl-acridine orange (960126-09-4) + N,N,N'-de-trimethyl-acridine orange (960126-21-0) + N,N'-de-dimethyl-acridine orange (960126-13-0) + N,N-de-dimethyl-acridine orange (960126-17-4) + proflavine hydrochloride (952-23-8)

Guidance literature:

With dihydrogen peroxide; nitric acid; iron(II) sulfate; In water; at 25 ℃; pH=3; pH-value; Concentration; Reagent/catalyst; Kinetics; Darkness;

DOI:10.1002/jccs.200900165

Reference yield: 100.0%

proflavine hydrochloride (952-23-8) + chloroacetyl chloride (79-04-9) → N,N’-(2-chloroacetamidyl)-3,6-acridine (51462-38-5)

Guidance literature:

at 100 ℃; for 6h;

DOI:10.1002/chem.201803732

upstream raw materials:

acridine orange

Downstream raw materials:

acridine

acridin-3-ylamine

dihydroxy-3,6 acridine

3-amino-6-azidoacridine

Refernces

• 1、 -. "Aminoacridine-α, β-(D)- or -(L)-N-glycoside derivatives, the salts thereof and a process for the preparation of such compounds". . . Retrieved 2008/06/13.