2,6-difluoro-3-nitrophenol

Base Information

• Chemical Name: 2,6-difluoro-3-nitrophenol
• CAS No.: 1393179-72-0
• Molecular Formula: C₆H₃F₂NO₃
• Molecular Weight: 175.092
• Mol file: 1393179-72-0.mol

Synonyms:2,6-difluoro-3-nitrophenol

Chemical Property of 2,6-difluoro-3-nitrophenol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-difluoro-3-nitrophenol

There total 3 articles about 2,6-difluoro-3-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.36%

2-(difluoromethoxy)-1,3-difluoro-4-nitrobenzene → 2,6-difluoro-3-nitrophenol (1393179-72-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 130 ℃; for 40h;

Reference yield:

2-(difluoromethoxy)-1,3-difluorobenzene → 2,6-difluoro-3-nitrophenol (1393179-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 0.5 h / -10 °C / Inert atmosphere

2: hydrogen bromide / acetic acid / 40 h / 130 °C

With sulfuric acid; hydrogen bromide; nitric acid; In acetic acid;

Reference yield:

2,6-difluorophenol (28177-48-2) → 2,6-difluoro-3-nitrophenol (1393179-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / water; N,N-dimethyl-formamide / 3 h / 100 °C

2: sulfuric acid; nitric acid / 0.5 h / -10 °C / Inert atmosphere

3: hydrogen bromide / acetic acid / 40 h / 130 °C

With sulfuric acid; hydrogen bromide; nitric acid; potassium carbonate; In water; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

2,6-difluorophenol

Refernces