Pamine Forte

Base Information

• Chemical Name: Pamine Forte
• CAS No.: 155-41-9
• Molecular Formula: C18H24NO4^.Br
• Molecular Weight: 398.297
• Hs Code.: 29399990
• European Community (EC) Number: 205-844-5
• Wikipedia: Methylscopolamine_bromide
• NCI Thesaurus Code: C47612
• RXCUI: 56092
• Mol file: 155-41-9.mol

Synonyms:Pamine Forte;Proscomide;Pamine;Ampyrox;Mescopil;Paraspan;Restropin;Scordin;Blocan;Diopal;Nutrop;Neo-Avagal;Lescopine bromide;Hyoscin methobromide;METHSCOPOLAMINE BROMIDE;Epoxymethamine bromide;Hyoscine methylbromide;Hyoscin-N-methylbromid;Hyoscine methyl bromide;Methoscopylamine bromide;Scopolamine methobromide;Methylscopolamine bromide;N-Methylhyoscine bromide;Scopolamine methylbromide;Scopolamin-N-methylbromid;Methylscopolamine hydrobromide;Holopan;N-Methylscopolammonium bromide;(-)-Scopolamine methyl bromide;HSDB 5420;Epoxytropine tropate methylbromide;Scopolammonium, N-methyl-, bromide;EINECS 205-844-5;SCOPOLAMMONIUM, N-METHYLBROMIDE;NSC 120606;Methylbromide scopolamine;scopolamine methyl bromide;U 0382;155-41-9;C18H24NO4.Br;Methscopolamine bromide [USP];C18-H24-N-O4.Br;1alphaH,5alphaH-Tropanium, 6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-, bromide, (-)-tropate;6beta,7beta-Epoxy-3alpha-hydroxy-8-methyl-1alphaH,5alphaH-tropanium bromide (-)-tropate;1-alpha-H,5-alpha-H-Tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-, bromide, (-)-tropate (ester);7-(3-Hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-3-oxo-9-azoniatricyclo-(3.3.1.0(2,4))nonane bromide;D04LHJ;C18H24NO4.HBr;SCHEMBL1652312;1-alpha-H,5-alpha-H-Tropanium, 6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-, bromide, (-)-tropate (ester);3-Oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane, 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, bromide, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-;3-Oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 7-((2S)-3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, bromide, (1alpha,2beta,4beta,5alpha,7beta)-;3-Oxa-9-azoniatricyclo[3.3.1.(2,4)]nonane, 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, bromide, [7(S)-(1.alpha.,2.beta.,4.beta.,5.alpha.,7beta)]-;3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, bromide, [7(S)-(1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)]-;3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-, bromide, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-;6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-1-alpha H,5-alpha H-tropanium bromide tropate (ester);AKOS026749843;LS-157838;1-alpha-H,5-alpha-H-Tropanium, 6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-, bromide,(-)-tropate (ester)

Chemical Property of Pamine Forte

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 214-217 °C (decomp)
• Refractive Index: -24 ° (C=1, H2O)
• PSA: 59.06000
• LogP: -1.97450
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 397.08887
• Heavy Atom Count: 24
• Complexity: 454

Purity/Quality:

99% ^*data from raw suppliers

Methscopolamine bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, N
• Hazard Codes: T,N,Xn
• Statements: 23/24/25-50/53-20/21/22-20/21
• Safety Statements: 36/37/39-45-61-60-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4)C.[Br-]
• Isomeric SMILES: C[N+]1([C@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(CO)C4=CC=CC=C4)C.[Br-]
• Uses: (?)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.10,11 anticholinergic METHSCOPOLAMINE BROMIDE is the methylated derivative of Scopolamine (S200000), a muscarinic antagonist that is similar to acetylcholine. METHSCOPOLAMINE BROMIDE have been used for the treatment of peptic ulcers by reducing acid secretion of the stomach and is used to treat morning sickness.
• Therapeutic Function: Spasmolytic

Technology Process of Pamine Forte

There total 4 articles about Pamine Forte which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl bromide (74-83-9) → methylscopolamine bromide (155-41-9)

Guidance literature:

With benzene;

DOI:10.1021/ja01595a051

Reference yield:

→ methylscopolamine bromide (155-41-9)

Guidance literature:

Herstellung von (-)-Scopolamin-<¹⁴C>methobromid;

DOI:10.1021/ja01595a051

Reference yield:

methyl bromide (74-83-9) → 6exo,7exo-epoxy-8,8-dimethyl-3endo-DL-tropoyloxy-nortropanium; bromide (155-41-9,150520-97-1)

Guidance literature:

With ethanol;

DOI:10.1002/ardp.19412790403

upstream raw materials:

methyl bromide

Downstream raw materials:

tiotropium bromide