Norfloxacin hydrochloride

Base Information

• Chemical Name: Norfloxacin hydrochloride
• CAS No.: 104142-93-0
• Molecular Formula: C₁₆H₁₈FN₃O₃*ClH
• Molecular Weight: 355.797
• Mol file: 104142-93-0.mol

Synonyms:3-Quinolinecarboxylicacid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride(9CI);

Chemical Property of Norfloxacin hydrochloride

Chemical Property:

• Vapor Pressure: 5.26E-14mmHg at 25°C
• Melting Point: 220 °C
• Boiling Point: 573.8oC at 760 mmHg
• Flash Point: 300.8oC
• PSA: 74.57000
• LogP: 2.46410
• Solubility.: insoluble in EtOH; ≥27.3 mg/mL in H2O; ≥5.05 mg/mL in DMSO with gentle warming

Purity/Quality:

99% ^*data from raw suppliers

Norfloxacinhydrochloride(1:x) 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Norfloxacin hydrochloride

There total 14 articles about Norfloxacin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (127142-90-9) → Norfloxacin hydrochloride (68077-27-0,104142-93-0)

Guidance literature:

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.3762/bjoc.15.212

Reference yield: 95.0%

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (70458-96-7) → Norfloxacin hydrochloride (68077-27-0,104142-93-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h;

Reference yield: 95.0%

C20H23BFN3O7 → Norfloxacin hydrochloride (68077-27-0,104142-93-0)

Guidance literature:

With hydrogenchloride; In water; at 0 ℃; for 4h; pH=< 1;

upstream raw materials:

piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate

Downstream raw materials:

7-(4-(N-(3-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-(4-(N-(2-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

7-(4-(N-(2-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-(4-(N-(4-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Refernces

• 1、 Peeters, Sara,Berntsen, Linn Neerbye,Rongved, P?l,Bonge-Hansen, Tore. "Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: Novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin". . p. 2156 - 2160. Retrieved 2019.
• 2、 -. "ANTIBIOTIC RESISTANCE BREAKERS". Page/Page column 100; 101. . Retrieved 2019/01/05.